Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Vujic, J; Schöllnast, H; Marsoner, K; Wienerroither, V; Bacher, H; Mischinger, HJ; Kornprat, P.
Marking Disappearing Colorectal Liver Metastases After Complete Response to Neoadjuvant Chemotherapy via CT - A Pilot Study.
Anticancer Res. 2019; 39(7):3847-3854
Doi: 10.21873/anticanres.13534
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Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Kornprat Peter
- Co-Autor*innen der Med Uni Graz
- Bacher Heinz
- Marsoner Katharina
- Mischinger Hans-Jörg
- Schoellnast Helmut
- Wienerroither Valerie Fanny
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- Abstract:
- BACKGROUND/AIM: The liver is a frequent site for metastases of colorectal cancer. Approximately 15% of patients have hepatic metastases at the time of diagnosis and another 50% develop them over the course of their disease. Only 10-25% of patients are candidates for liver resection. The aim of this study was to assess the benefit of preoperative computed tomography (CT)-guided wire marking of disappearing colorectal liver metastases (CRLMs) (radiological disappearance of metastases) before surgical resection. PATIENTS AND METHODS: Between January 2011 and January 2014, 20 patients with potentially disappearing CRLMs were selected for CT-guided wire marking. Following treatment with neoadjuvant chemotherapy, disappearing CRLMs were marked via CT guidance. Afterwards, the marked sites were resected. RESULTS: Complete histological response to neoadjuvant chemotherapy was only in 10 resected sites (18%), and 46 (82%) resected liver metastases showed metastatic tissue present. Both overall survival and the disease-free rates in patients after using our method were 55%. CONCLUSION: This study demonstrated the usefulness of CT-guided wire marking to mark disappearing CRLMs in order to improve long-term effectiveness of surgical treatment.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged - administration & dosage
- Antineoplastic Agents - therapeutic use
- Colorectal Neoplasms - diagnostic imaging, drug therapy, pathology, surgery
- Female - administration & dosage
- Humans - administration & dosage
- Liver Neoplasms - diagnostic imaging, drug therapy, secondary, surgery
- Male - administration & dosage
- Middle Aged - administration & dosage
- Neoadjuvant Therapy - administration & dosage
- Pilot Projects - administration & dosage
- Survival Analysis - administration & dosage
- Tomography, X-Ray Computed - administration & dosage
- Find related publications in this database (Keywords)
- Disappearing liver metastases
- wire marking
- colon cancer
- complete radiological response