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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Mangge, H; Bengesser, S; Dalkner, N; Birner, A; Fellendorf, F; Platzer, M; Queissner, R; Pilz, R; Maget, A; Reininghaus, B; Hamm, C; Bauer, K; Rieger, A; Zelzer, S; Fuchs, D; Reininghaus, E.
Weight Gain During Treatment of Bipolar Disorder (BD)-Facts and Therapeutic Options.
Front Nutr. 2019; 6: 76-76.
Doi: 10.3389/fnut.2019.00076
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- Leading authors Med Uni Graz
- Bengesser Susanne
- Mangge Harald
- Co-authors Med Uni Graz
- Bauer Konstantin
- Birner Armin
- Dalkner Nina
- Fellendorf Frederike
- Hamm Carlo
- Maget Alexander
- Pilz Rene
- Platzer Martina
- Queissner Robert
- Reininghaus Bernd
- Reininghaus Eva
- Reiter Alexandra
- Zelzer Sieglinde
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- Abstract:
- Bipolar disorder (BPD) is a mood disorder, which is characterized by alternating affective states, namely (hypo)mania, depression, and euthymia. Evidence is growing that BPD has indeed a biologic substrate characterized by chronic inflammation, oxidative stress, and disturbed energy metabolism. Apart from this, there is obviously a hereditary component of this disease with multi-genetic factors. Most probably a susceptibility threshold favors the outbreak of clinical disease after a cascade of stress events that remain to be elucidated in more detail. Evidence is also growing that weak points in brain energy metabolism contribute to outbreak and severity of BPD. Conventional psychopharmacologic therapy must be reassessed under the aspects of weight cycling and development of central obesity as a deterioration factor for a worse clinical course leading to early cardiovascular events in BPD subgroups.
- Find related publications in this database (Keywords)
- bipolar disorder
- weight gain
- inflammation
- obesity
- oxidative stress
- biochemistry