Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Bao, Y; Ledderose, C; Seier, T; Graf, AF; Brix, B; Chong, E; Junger, WG.
Mitochondria regulate neutrophil activation by generating ATP for autocrine purinergic signaling.
J Biol Chem. 2014; 289(39):26794-26803 Doi: 10.1074/jbc.M114.572495 [OPEN ACCESS]
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Co-Autor*innen der Med Uni Graz: Steuber Bianca
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Abstract:: Polymorphonuclear neutrophils (PMNs) form the first line of defense against invading microorganisms. We have shown previously that ATP release and autocrine purinergic signaling via P2Y2 receptors are essential for PMN activation. Here we show that mitochondria provide the ATP that initiates PMN activation. Stimulation of formyl peptide receptors increases the mitochondrial membrane potential (Δψm) and triggers a rapid burst of ATP release from PMNs. This burst of ATP release can be blocked by inhibitors of mitochondrial ATP production and requires an initial formyl peptide receptor-induced Ca(2+) signal that triggers mitochondrial activation. The burst of ATP release generated by the mitochondria fuels a first phase of purinergic signaling that boosts Ca(2+) signaling, amplifies mitochondrial ATP production, and initiates functional PMN responses. Cells then switch to glycolytic ATP production, which fuels a second round of purinergic signaling that sustains Ca(2+) signaling via P2X receptor-mediated Ca(2+) influx and maintains functional PMN responses such as oxidative burst, degranulation, and phagocytosis. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.
Find related publications in this database (using NLM MeSH Indexing): Adenosine Triphosphate - immunology; Adenosine Triphosphate - metabolism; Autocrine Communication - physiology; Calcium Signaling - physiology; Cell Degranulation - physiology; Female -; Humans -; Male -; Mitochondria - immunology; Mitochondria - metabolism; Neutrophil Activation - physiology; Neutrophils - cytology; Neutrophils - immunology; Neutrophils - metabolism; Phagocytosis - physiology; Receptors, Purinergic P2X - immunology; Receptors, Purinergic P2X - metabolism; Respiratory Burst - physiology