Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Schinkovitz, A; Kaur, A; Urban, E; Zehl, M; Páchniková, G; Wang, Y; Kretschmer, N; Slaninová, I; Pauli, GF; Franzblau, SG; Krupitza, G; Bauer, R; Kopp, B.
Cytotoxic constituents from Lobaria scrobiculata and a comparison of two bioassays for their evaluation.
J Nat Prod. 2014; 77(4):1069-1073
Doi: 10.1021/np4008574
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PubMed
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- Co-Autor*innen der Med Uni Graz
- Kretschmer Nadine
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- Abstract:
- Lichens are resilient organisms, known for their unique profiles of secondary metabolites and for exhibiting antioxidative, antibacterial, and cytotoxic effects. Analyzing the cytotoxic potential of Lobaria scrobiculata, a bioassay-guided fractionation strategy yielded seven known metabolites, with two of these compounds, 2 and 3, exhibiting cytotoxicity against HL-60 cells. In order to verify the potential impact of degradation on observed bioactivity, a purity and stability evaluation was conducted. The consistency of results obtained by the water-soluble tetrazolium salt-1 assay and trypan blue cytotoxicity assay was evaluated for selected compounds.
- Find related publications in this database (using NLM MeSH Indexing)
- Anti-Bacterial Agents - metabolism
- Antineoplastic Agents, Phytogenic - chemistry
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- Antineoplastic Agents, Phytogenic - pharmacology
- Benzofurans - chemistry
- Benzofurans - pharmacology
- Drug Screening Assays, Antitumor -
- Drug Screening Assays, Antitumor -
- HL-60 Cells -
- Humans -
- Lichens - chemistry
- Molecular Structure -
- Nuclear Magnetic Resonance, Biomolecular -
- Phenols - chemistry
- Phenols - isolation & purification
- Phenols - pharmacology
- Trypan Blue - pharmacology