Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
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SHR Neuro Krebs Kardio Lipid Stoffw Microb
Katanić, J; Pferschy-Wenzig, EM; Mihailović, V; Boroja, T; Pan, SP; Nikles, S; Kretschmer, N; Rosić, G; Selaković, D; Joksimović, J; Bauer, R.
Phytochemical analysis and anti-inflammatory effects of Filipendula vulgaris Moench extracts.
Food Chem Toxicol. 2018; 122(11):151-162
Doi: 10.1016/j.fct.2018.10.001
Web of Science
PubMed
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FullText_MUG
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- Kretschmer Nadine
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- Abstract:
- Filipendula vulgaris Moench (dropwort) is used in traditional medicine for relieving various inflammation-related diseases. In the present study, the phytochemical profile of F. vulgaris aerial part (FVA) and root (FVR) methanolic extracts was evaluated by LC-DAD-HRMS analysis. Furthermore, their in vitro and in vivo anti-inflammatory effects, as well as their potential cytotoxicity, were assessed. Results showed that the extracts mainly contain phenolics like flavonoids, hydrolyzable tannins, procyanidins, and phenolic acid derivatives, including gaultherin. No in vitro cytotoxicity was found at the highest concentration (50 μg/mL). FVA extract (50 μg/mL) significantly inhibited cyclooxygenase-1 and -2 (COX-1 and COX-2) activities in vitro (>50% inhibition), and FVR extract considerably inhibited COX-2 activity (52.5 ± 2.7%) without affecting COX-2 gene expression in LPS-stimulated THP-1 cells. The extracts demonstrated prominent in vivo anti-inflammatory potential upon oral administration in rats. Especially FVA extract at 100 and 200 mg/kg significantly inhibited carrageenan-induced edema formation. From these results, it can be concluded that F. vulgaris extracts possess interesting anti-inflammatory properties. Copyright © 2018 Elsevier Ltd. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Anti-Inflammatory Agents - administration & dosage
- Anti-Inflammatory Agents - pharmacology
- Cell Line -
- Cell Line, Tumor -
- Chromatography, Liquid - methods
- Cyclooxygenase 1 - drug effects
- Cyclooxygenase 1 - genetics
- Cyclooxygenase 1 - metabolism
- Cyclooxygenase 2 - drug effects
- Cyclooxygenase 2 - genetics
- Cyclooxygenase 2 - metabolism
- Cyclooxygenase Inhibitors - pharmacology
- Dose-Response Relationship, Drug -
- Filipendula - chemistry
- Free Radical Scavengers - pharmacology
- Gene Expression -
- Humans -
- Inhibitory Concentration 50 -
- Male -
- Mass Spectrometry - methods
- Methanol - chemistry
- Nitric Oxide - metabolism
- Phytochemicals - chemistry
- Phytochemicals - pharmacology
- Plant Components, Aerial - chemistry
- Plant Extracts - chemistry
- Plant Extracts - pharmacology
- Plant Roots - chemistry
- Rats, Wistar -
- Find related publications in this database (Keywords)
- Biological activity
- Cytotoxicity
- Inflammation
- Filipendula vulgaris
- LC-DAD-HRMS analysis