Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Bernaskova, M; Kretschmer, N; Schuehly, W; Huefner, A; Weis, R; Bauer, R.
Synthesis of tetrahydrohonokiol derivates and their evaluation for cytotoxic activity against CCRF-CEM leukemia, U251 glioblastoma and HCT-116 colon cancer cells.
Molecules. 2014; 19(1):1223-1237
Doi: 10.3390/molecules19011223
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- Co-Autor*innen der Med Uni Graz
- Kretschmer Nadine
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- Abstract:
- Biphenyl neolignans such as honokiol and magnolol, which are the major active constituents of the Asian medicinal plant Magnolia officinalis, are known to exert a multitude of pharmacological and biological activities. Among these, cytotoxic and tumor growth inhibitory activity against various tumour cell lines are well-documented. To further elucidate the cytotoxic effects of honokiol derivatives, derivatizations were performed using tetrahydrohonokiol as a scaffold. The derivatizations comprised the introduction of functional groups, e.g., nitro and amino groups, as well as alkylation. This way, 18 derivatives, of which 13 were previously undescribed compounds, were evaluated against CCRF-CEM leukemia cells, U251 glioblastoma and HCT-116 colon cancer cells. The results revealed no significant cytotoxic effects in any of the three tested cell lines at a test concentration of 10 µM.
- Find related publications in this database (using NLM MeSH Indexing)
- Antineoplastic Agents, Phytogenic - chemical synthesis
- Antineoplastic Agents, Phytogenic - pharmacology
- Biphenyl Compounds - chemical synthesis
- Biphenyl Compounds - pharmacology
- Cell Survival - drug effects
- Colonic Neoplasms -
- Drug Screening Assays, Antitumor -
- Glioblastoma -
- HCT116 Cells -
- Humans -
- Inhibitory Concentration 50 -
- Leukemia -
- Lignans - chemical synthesis
- Lignans - pharmacology
- Methylation -
- Microwaves -
- Find related publications in this database (Keywords)
- tetrahydrohonokiol derivatives
- cytotoxicity
- CCRF-CEM leukemia cells
- U251 glioblastoma
- HCT-116 colon cancer cells
- Magnolia officinalis