Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Katanić, J; Matić, S; Pferschy-Wenzig, EM; Kretschmer, N; Boroja, T; Mihailović, V; Stanković, V; Stanković, N; Mladenović, M; Stanić, S; Mihailović, M; Bauer, R.
Filipendula ulmaria extracts attenuate cisplatin-induced liver and kidney oxidative stress in rats: In vivo investigation and LC-MS analysis.
Food Chem Toxicol. 2017; 99(2):86-102
Doi: 10.1016/j.fct.2016.11.018
Web of Science
PubMed
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- Kretschmer Nadine
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- Abstract:
- Filipendula ulmaria, known as meadowsweet, is a perennial herb found in wild and cultivated habitats in Europe and Asia. Usage of F. ulmaria in traditional medicine is based on diuretic, astringent, antirheumatic, and anti-inflammatory properties of this plant. Exposure to cisplatin at a dose of 7.5 mg/kg caused significant increase in serum parameters of liver and kidneys function and tissue oxidative stress markers along with some histopathological changes in liver and kidney tissues of experimental rats, as well as high level of genotoxicity. Administration of F. ulmaria extracts in three different concentrations (100, 200, and 400 mg/kg/day) for 10 days resulted in a reduction of oxidative stress in tissues and decrease of serum parameters. Moreover, tested extracts attenuated the genotoxicity of cisplatin in reverse dose-dependent manner. F. ulmaria extracts had no in vitro cytotoxic activity at all applied concentrations (IC50 > 50 μg/mL). Tested extracts, rich in polyphenolic compounds, attenuate cisplatin-induced liver and kidney oxidative stress, reduce tissue damage, and enhance the antioxidative status of experimental animals during cisplatin application. Therefore, F. ulmaria extracts may be used as supportive agent for the prevention and amelioration of cisplatin side effects. Copyright © 2016 Elsevier Ltd. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Antineoplastic Agents - toxicity
- Cell Survival - drug effects
- Chemical and Drug Induced Liver Injury - etiology
- Chemical and Drug Induced Liver Injury - prevention & control
- Chromatography, Liquid - methods
- Cisplatin - toxicity
- DNA Damage - drug effects
- Filipendula - chemistry
- Kidney - drug effects
- Kidney - metabolism
- Kidney Diseases - chemically induced
- Kidney Diseases - prevention & control
- Liver - drug effects
- Liver - metabolism
- Mass Spectrometry - methods
- Oxidative Stress - drug effects
- Plant Extracts - pharmacology
- Rats -
- Rats, Wistar -
- Find related publications in this database (Keywords)
- Filipendula ulmaria
- LC-DAD-MSn analysis
- Cisplatin
- Oxidative stress
- Genotoxicity
- Cytotoxicity