Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Damianakos, H; Kretschmer, N; Sykłowska-Baranek, K; Pietrosiuk, A; Bauer, R; Chinou, I.
Antimicrobial and cytotoxic isohexenylnaphthazarins from Arnebia euchroma (Royle) Jonst. (Boraginaceae) callus and cell suspension culture.
Molecules. 2012; 17(12):14310-14322
Doi: 10.3390/molecules171214310
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- Co-Autor*innen der Med Uni Graz
- Kretschmer Nadine
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- Abstract:
- The phytochemical investigation of the n-hexane extract from callus and cell suspension culture of Arnebia euchroma (Royle) Jonst. resulted in the isolation of nine isohexenylnaphthazarins: deoxyalkannin (1), alkannin (2), acetylalkannin (3), isobutyrylalkannin (4), β-hydroxyisovalerylalkannin (5), 2''-(S)-α-methylbutyrylalkannin (6), propionylalkannin (7), teracrylalkannin (8) and acetylshikonin (9). Their structures were determined by MS and NMR spectroscopy. Pigments 2–8 are isolated for the first time from Arnebia in vitro cultures, 4 and 7 are reported in the present work as novel metabolites within the Arnebia genus, while 9 is a known constituent of both natural roots and in vitro cultures of A. euchroma. Moreover, methyl jasmonate and 1-monoglyceryl olate, palmitate and stearate are reported for the first time within the Boraginaceae family. The antimicrobial and cytotoxic activities of all isolated pigment compounds were tested, revealing a very interesting profile.
- Find related publications in this database (using NLM MeSH Indexing)
- Anti-Infective Agents - pharmacology
- Bacteria - drug effects
- Boraginaceae - chemistry
- Cell Culture Techniques -
- Cell Proliferation - drug effects
- Humans -
- Naphthoquinones - chemistry
- Naphthoquinones - isolation & purification
- Naphthoquinones - pharmacology
- Plant Extracts - chemistry
- Plant Extracts - pharmacology
- Plant Roots - chemistry
- Find related publications in this database (Keywords)
- Arnebia euchroma
- Boraginaceae
- callus culture
- cell suspension culture
- isohexenylnaphthazarins
- cytotoxic
- antimicrobial