Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Kretschmer, N; Blunder, M; Kunert, O; Rechberger, GN; Bauer, R; Schuehly, W.
Cytotoxic furanogermacranolides from the flowers of Helianthus angustifolius.
Planta Med. 2011; 77(17):1912-1915
Doi: 10.1055/s-0031-1279994
Web of Science
PubMed
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- Kretschmer Nadine
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- Abstract:
- The dichloromethane extract of the flowers of Helianthus angustifolius L. (Asteraceae, Heliantheae) was investigated in vitro for its cytotoxic activity using human cancer cell lines: CCRF-CEM leukemia, MDA-MB-231 breast cancer, U251 glioblastoma, HCT 116 colon cancer cells, and the human lung fibroblast cell line MRC-5. Cytotoxicity-guided fractionation led to the isolation of four related heliangolide-type sesquiterpene lactones. The structures were elucidated by means of NMR spectroscopy and high-resolution mass spectrometry. Of the investigated compounds, 8-methacrylyl-4,15-iso-atriplicolide (1) showed the highest activity against all tested cancer cell lines with IC₅₀ values ranging from 0.26 ± 0.01 µM for CCRF-CEM cells to 4.22 ± 0.26 µM for MRC-5 cells. © Georg Thieme Verlag KG Stuttgart · New York.
- Find related publications in this database (using NLM MeSH Indexing)
- Antineoplastic Agents, Phytogenic - chemistry
- Antineoplastic Agents, Phytogenic - isolation & purification
- Antineoplastic Agents, Phytogenic - pharmacology
- Cell Line, Tumor -
- Flowers - chemistry
- Helianthus - chemistry
- Humans -
- Inhibitory Concentration 50 -
- Lactones - chemistry
- Lactones - isolation & purification
- Lactones - pharmacology
- Magnetic Resonance Spectroscopy -
- Mass Spectrometry -
- Plant Extracts - chemistry
- Plant Extracts - isolation & purification
- Plant Extracts - pharmacology
- Plants, Medicinal - chemistry
- Sesquiterpenes - chemistry
- Sesquiterpenes - isolation & purification
- Sesquiterpenes - pharmacology
- Find related publications in this database (Keywords)
- Helianthus angustifolius
- Asteraceae
- heliangolide
- isoatriplicolide
- cancer cell lines
- MRC-5 lung fibroblast cells