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SHR Neuro Cancer Cardio Lipid Metab Microb

Bratuša, A; Elschner, T; Heinze, T; Fröhlich, E; Hribernik, S; Božič, M; Žagar, E; Kleinschek, KS; Thonhofer, M; Kargl, R.
Functional dextran amino acid ester particles derived from N-protected S-trityl-L-cysteine.
Colloids Surf B Biointerfaces. 2019; 181(8):561-566 Doi: 10.1016/j.colsurfb.2019.06.005
Web of Science PubMed FullText FullText_MUG

Co-authors Med Uni Graz: Fröhlich Eleonore
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Abstract:: This work describes the derivatization of dextran using N-(tert-butyloxycarbonyl)-S-(trityl)-L-cysteine in the presence of N,N'-carbonyldiimidazole (CDI) as a coupling agent. Homogeneous reactions in dimethyl sulfoxide allowed for an efficient coupling of the amino acid derivative to the polymer backbone. Derivatization was confirmed by infrared and ¹³C NMR spectroscopy, size exclusion chromatography and elemental analysis. The presence of hydrophobic protecting groups resulted in a product that can be shaped into water-insoluble particles stable in an aqueous environment and non-toxic for lung epithelial cells. It is suggested that materials composed of ester bonds between amino acids and polysaccharides are useful for targeted drug delivery, bio-imaging or surface functionalization. Copyright © 2019. Published by Elsevier B.V.
Find related publications in this database (Keywords): Dextran; Bio-Conjugation; Micro-/nano-particles; Emulsion precipitation; Cytotoxicity; Zeta-Potential