Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Bratuša, A; Elschner, T; Heinze, T; Fröhlich, E; Hribernik, S; Božič, M; Žagar, E; Kleinschek, KS; Thonhofer, M; Kargl, R.
Functional dextran amino acid ester particles derived from N-protected S-trityl-L-cysteine.
Colloids Surf B Biointerfaces. 2019; 181(8):561-566
Doi: 10.1016/j.colsurfb.2019.06.005
Web of Science
PubMed
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FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Fröhlich Eleonore
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- Abstract:
- This work describes the derivatization of dextran using N-(tert-butyloxycarbonyl)-S-(trityl)-L-cysteine in the presence of N,N'-carbonyldiimidazole (CDI) as a coupling agent. Homogeneous reactions in dimethyl sulfoxide allowed for an efficient coupling of the amino acid derivative to the polymer backbone. Derivatization was confirmed by infrared and 13C NMR spectroscopy, size exclusion chromatography and elemental analysis. The presence of hydrophobic protecting groups resulted in a product that can be shaped into water-insoluble particles stable in an aqueous environment and non-toxic for lung epithelial cells. It is suggested that materials composed of ester bonds between amino acids and polysaccharides are useful for targeted drug delivery, bio-imaging or surface functionalization. Copyright © 2019. Published by Elsevier B.V.
- Find related publications in this database (Keywords)
- Dextran
- Bio-Conjugation
- Micro-/nano-particles
- Emulsion precipitation
- Cytotoxicity
- Zeta-Potential