Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Römer, M; Painsipp, E; Schwetz, I; Holzer, P.
Facilitation of gastric compliance and cardiovascular reaction by repeated isobaric distension of the rat stomach.
NEUROGASTROENTEROL MOTIL. 2005; 17(3): 399-409.
Doi: 10.1111/j.1365-2982.2005.00649.x
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- Führende Autor*innen der Med Uni Graz
- Holzer Peter
- Co-Autor*innen der Med Uni Graz
- Singewald Evelin
- Zollner-Schwetz Ines
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- Abstract:
- Gastric distension causes cardiovascular reactions and enhances gastric compliance. Here, we investigated how these responses are related to each other, whether they change upon repeated distension and which neural mechanisms are involved. Mean arterial blood pressure (MAP) in phenobarbital-anaesthetized rats was recorded from a carotid artery and gastric compliance determined with an electronic barostat. Runs of intermittent gastric distension were generated by stepwise increments (5 mmHg) of intragastric (IG) pressure. While gastric compliance peaked at IG pressures of 20 mmHg, the change in MAP (predominantly hypotension) was largest at IG pressures beyond 30 mmHg. Repeated distension enhanced the MAP response to IG pressures beyond 35 mmHg, whereas gastric compliance was facilitated primarily at IG pressures below 20 mmHg. This facilitation of gastric compliance depended on the magnitude of the preceding distension. The MAP response to distension was enhanced by nitric oxide synthase inhibition, inhibited by subdiaphragmatic vagotomy but hardly affected by coeliac ganglionectomy. The facilitation of gastric compliance was changed by vagotomy in a complex manner but left unaltered by the other interventions. These findings show that isobaric gastric distension elicits both MAP and gastric compliance responses whose characteristics, mechanisms and sensitization properties differ profoundly.
- Find related publications in this database (using NLM MeSH Indexing)
- Air Pressure -
- Animals -
- Blood Pressure - physiology
- Compliance - physiology
- Denervation - physiology
- Enzyme Inhibitors - pharmacology
- Female - pharmacology
- Ganglia, Sympathetic - physiology
- Gastric Acid - physiology
- Hemodynamic Processes - physiology
- In Vitro - physiology
- Manometry - physiology
- NG-Nitroarginine Methyl Ester - pharmacology
- Neural Pathways - physiology
- Nitric Oxide - physiology
- Nitric Oxide Synthase - antagonists and inhibitors
- Physical Stimulation - antagonists and inhibitors
- Rats - antagonists and inhibitors
- Rats, Sprague-Dawley - antagonists and inhibitors
- Research Support, Non-U.S. Gov't - antagonists and inhibitors
- Stomach - innervation
- Stress, Mechanical - innervation
- Vagotomy - innervation
- Find related publications in this database (Keywords)
- cardiovascular reaction to gastric distension
- electronic barostat
- extrinsic innervation of the stomach
- facilitation of gastric compliance on repeated gastric distension
- gastric accommodation