Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Nachbaur, D; Greinix, HT; Koller, E; Krieger, O; Linkesch, W; Kasparu, H; Pober, M; Hinterberger, W; Hausmaninger, H; Heistinger, M; Ulsperger, E; Karlhuber, S; Schwinger, W; Lindner, B.
Long-term results of autologous stem cell transplantation for Hodgkin's disease (HD) and low-/intermediate-grade B non-Hodgkin's lymphoma (NHL): a report from the Austrian Stem Cell Transplantation Registry (ASCTR).
Ann Hematol. 2005; 84(7):462-473
Doi: 10.1007/s00277-004-1003-3
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- Co-Autor*innen der Med Uni Graz
- Greinix Hildegard
- Linkesch Werner
- Schwinger Wolfgang
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- Abstract:
- Between 1990 and 2001, 68 patients with advanced Hodgkin's disease (HD) and 86 patients classified as low-/intermediate-grade B non-Hodgkin's lymphoma (NHL) were reported to the Austrian Stem Cell Transplantation Registry (ASCTR). Following autologous stem cell transplantation (SCT) for HD, overall survival was 56% [95% confidence interval (CI): 40-72%] with a disease-/progression-free survival of 49%, reaching a plateau at 5 years. Using multivariate Cox regression analysis BEAM conditioning (carmustine, cytarabine, etoposide and melphalan) was predictive for favourable outcome, better disease-/progression-free survival and a significantly lower risk for relapse. The cumulative incidence of relapse was 30%, even for patients in complete remission at time of SCT. The cumulative risk for developing a secondary malignancy increased continuously over time, achieving 20% at 7 years and 46% at 10 years with previous radiotherapy as the only risk factor in the multivariate analysis. Overall survival for NHL patients was 45% (95% CI: 26-64%) with a disease-/progression-free survival of 26% at 7 years. In the multivariate Cox regression analysis stage of disease at time of SCT was the most powerful parameter for overall survival, disease-/progression-free survival and relapse. Mantle cell lymphoma, greater than or equal to three lines of previous therapy, and a conditioning regimen other than BEAM were also predictive for death. The main reason for treatment failure was relapse (cumulative incidence 54-75%). Because of the high risk of relapse/progression in both disease categories and the additional high rate of second malignancies in HD patients, allogeneic stem cells should be considered a valuable alternative for selected patients. The efficacy of allotransplantation following reduced-intensity conditioning should be tested in randomised trials.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Adult -
- Child -
- Disease-Free Survival -
- Female -
- Hematopoietic Stem Cell Transplantation -
- Hodgkin Disease - mortality Hodgkin Disease - therapy
- Humans -
- Longitudinal Studies -
- Male -
- Middle Aged -
- Recurrence -
- Registries -
- Remission Induction -
- Retrospective Studies -
- Transplantation, Autologous -
- Treatment Outcome -
- Find related publications in this database (Keywords)
- autologous
- transplantation
- non-Hodgkin's lymphoma
- Hodgkin's disease
- long-term results