Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Egemnazarov, B; Kwapiszewska, G; Marsh, LM.
Echocardiographic Measurement of Right Ventricular Diastolic Parameters in Mouse.
J Vis Exp. 2019; 10(146):
Doi: 10.3791/58021
Web of Science
PubMed
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FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Egemnazarov Bakytbek
- Co-Autor*innen der Med Uni Graz
- Kwapiszewska-Marsh Grazyna
- Marsh Leigh
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- Abstract:
- Diastolic dysfunction is a prominent feature of right ventricular (RV) remodeling associated with conditions of pressure overload. However, the RV diastolic function is rarely quantified in experimental studies. This might be due to technical difficulties in the visualization of the RV in the apical four-chamber view in rodents. Here we describe two positions facilitating the visualization of the apical four-chamber view in mice to assess the RV diastolic function. The apical four-chamber view is enabled by tilting the mouse fixation platform to the left and caudally (LeCa) or to the right and cranially (RiCr). Both positions provide images of comparable quality. The results of the RV diastolic function obtained from two positions are not significantly different. Both positions are comparably easy to perform. This protocol can be incorporated into published protocols and enables detailed investigations of the RV function.
- Find related publications in this database (Keywords)
- Medicine
- Issue 146
- Mouse
- echocardiography
- right ventricle
- diastole
- diastolic parameters
- dysfunction
- pulmonary artery banding