Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Pellicano, M; Di Gioia, G; Ciccarelli, G; Xaplanteris, P; Delrue, L; Toth, GG; Van Durme, F; Heyse, A; Wyffels, E; Vanderheyden, M; Bartunek, J; De Bruyne, B; Barbato, E.
Procedural microvascular activation in long lesions treated with bioresorbable vascular scaffolds or everolimus-eluting stents: the PROACTIVE trial.
EuroIntervention. 2020; 16(2):e147-e154-e147-e154
Doi: 10.4244/EIJ-D-18-01138
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- Co-authors Med Uni Graz
- Toth-Gayor Gabor
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- Abstract:
- Significant platelet activation after long stented coronary segments has been associated with periprocedural microvascular impairment and myonecrosis. In long lesions treated either with an everolimus-eluting bioresorbable vascular scaffold (BVS) or an everolimus-eluting stent (EES), we aimed to investigate (a) procedure-related microvascular impairment, and (b) the relationship of platelet activation with microvascular function and related myonecrosis. Patients (n=66) undergoing elective percutaneous coronary intervention (PCI) in long lesions were randomised 1:1 to either BVS or EES. The primary endpoint was the difference between groups in changes of pressure-derived corrected index of microvascular resistance (cIMR) after PCI. Periprocedural myonecrosis was assessed by high-sensitivity cardiac troponin T (hs-cTnT), platelet reactivity by high-sensitivity adenosine diphosphate (hs-ADP)-induced platelet reactivity with the Multiplate Analyzer. Post-dilatation was more frequent in the BVS group, with consequent longer procedure time. A significant difference was observed between the two groups in the primary endpoint of ΔcIMR (p=0.04). hs-ADP was not different between the groups at different time points. hs-cTnT significantly increased after PCI, without difference between the groups. In long lesions, BVS implantation is associated with significant acute reduction in IMR as compared with EES, with no significant interaction with platelet reactivity or periprocedural myonecrosis.
- Find related publications in this database (using NLM MeSH Indexing)
- Absorbable Implants -
- Coronary Angiography - methods
- Coronary Artery Disease - diagnostic imaging
- Coronary Artery Disease - surgery
- Drug-Eluting Stents - adverse effects
- Everolimus - administration & dosage
- Everolimus - therapeutic use
- Humans -
- Percutaneous Coronary Intervention - adverse effects
- Percutaneous Coronary Intervention - methods
- Postoperative Complications - diagnostic imaging
- Postoperative Complications - prevention & control
- Prosthesis Design -
- Tissue Scaffolds -
- Tomography, Optical Coherence - methods
- Treatment Outcome -
- Find related publications in this database (Keywords)
- bioresorbable scaffolds
- drug-eluting stent
- fractional flow reserve
- other technique
- stable angina