Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Kau, T; Gasser, J; Celedin, S; Rabitsch, E; Eicher, W; Uhl, E; Hausegger, KA.
MR angiographic follow-up of intracranial aneurysms treated with detachable coils: evaluation of a blood-pool contrast medium.
AJNR Am J Neuroradiol. 2009; 30(8): 1524-1530.
Doi: 10.3174/ajnr.A1622
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- Führende Autor*innen der Med Uni Graz
- Kau Thomas
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- Abstract:
- Blood-pool agents are promising in the imaging of small vessels with slow or complex flow. Our aim was to compare blood-pool contrast-enhanced MR angiography (BPCE-MRA) using gadofosveset trisodium (Vasovist) with 3D time-of-flight MRA (TOF-MRA) in the follow-up of intracranial aneurysms after endovascular therapy. We included 32 patients with a total of 37 coiled aneurysms. MRAs in the early steady-state phase were performed on a 1.5T scanner within 8 days of digital subtraction angiography (DSA). Two radiologists independently analyzed TOF-MRA and BPCE-MRA images. Consensus was reached by review involving a third neuroradiologist. DSA images were interpreted separately by an interventional radiologist. Findings were assigned to 1 of 3 categories: 1) complete occlusion, 2) residual neck, and 3) residual aneurysm. Follow-up DSA demonstrated 13 complete obliterations (class 1), 13 residual necks (class 2), and 11 residual aneurysms (class 3). Weighted kappa statistics showed substantial concordance of TOF-MRA and DSA (0.664) as well as BPCE-MRA and DSA (0.724) ratings. Comparison between TOF-MRA and BPCE-MRA found excellent agreement (0.818) with only 6 (16.2%) discrepancies. For detecting residual flow, the difference in accuracy of both MRA techniques (83.8% versus 91.9%) was not significant (McNemar, P = 1.000). BPCE-MRA showed a tendency towards higher sensitivity and specificity (91.7% and 92.3%, respectively) compared with TOF-MRA (87.5% and 76.9%). In classifying the completeness of endovascular cerebral aneurysm therapy, we found that BPCE-MRA and 3D TOF-MRA showed very good agreement. The use of Vasovist did not lead to a significantly increased accuracy of MRA follow-up.
- Find related publications in this database (using NLM MeSH Indexing)
- Contrast Media -
- Device Removal -
- Embolization, Therapeutic - instrumentation
- Female -
- Follow-Up Studies -
- Gadolinium -
- Gated Blood-Pool Imaging - methods
- Humans -
- Image Enhancement - methods
- Intracranial Aneurysm - diagnosis
- Intracranial Aneurysm - surgery
- Magnetic Resonance Angiography - methods
- Male -
- Middle Aged -
- Organometallic Compounds -
- Reproducibility of Results -
- Sensitivity and Specificity -