Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Blumenthal, J; Moore, DJ; Jain, S; Sun, X; Ellorin, E; Corado, K; Hoenigl, M; Dube, M; Haubrich, R; Morris, SR.
Recent HIV Risk Behavior and Partnership Type Predict HIV Pre-Exposure Prophylaxis Adherence in Men Who Have Sex with Men.
AIDS Patient Care STDS. 2019; 33(5):220-226
Doi: 10.1089/apc.2018.0289
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Hönigl Martin
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Men who have sex with men (MSM) reporting higher HIV risk behavior over time are often more adherent to pre-exposure prophylaxis (PrEP), but it is unclear if recent risk behavior and partnership type affect long-term PrEP adherence. HIV-negative MSM and transgender women completing the 48-week randomized study TAPIR (Daily Text Messages to Support Adherence to PrEP in At-Risk for HIV Individuals) were included. At baseline and weeks 24 and 48, a modified Calculated Risk (mCalcR) Score estimated the likelihood of HIV seroconversion over 1 year based on reported condomless anal sex acts in the last month and current sexually transmitted infection. mCalcR scores were categorized as low, moderate, and high/very high risk. Partnership type was classified as no partner/single HIV-negative partner (no/single-), single HIV-positive partner (single+), or multiple partners of any serostatus (multi) in the past 3 months. PrEP adherence was measured by intracellular tenofovir-diphosphate (TFV-DP) levels. Among 313 individuals, there was no difference in mCalcR category from baseline to week 48. There was a significant change in partnership type, with no/single partnerships increasing from 0.5% to 9%. Participants with moderate and high/very risk had higher TFV-DP levels than the low-risk group. No/single participants had lower TFV-DP levels than those reporting single+ or multi. Although there was a shift toward lower-risk partnerships, HIV risk category remained stable over time. Individuals with riskier behaviors and partnerships had higher PrEP drug levels, suggesting continued motivation for and adherence to PrEP.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Anti-HIV Agents - administration & dosage
- Anti-HIV Agents - therapeutic use
- Female -
- HIV Infections - drug therapy
- HIV Infections - prevention & control
- Homosexuality, Male - psychology
- Humans -
- Male -
- Medication Adherence -
- Middle Aged -
- Pre-Exposure Prophylaxis - methods
- Risk-Taking -
- Sexual Partners -
- Tenofovir - administration & dosage
- Tenofovir - therapeutic use
- Young Adult -
- Find related publications in this database (Keywords)
- HIV prevention
- pre-exposure prophylaxis (PrEP)
- HIV risk
- partnerships
- men who have sex with men (MSM)
- medication adherence