Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Ghaffari-Tabrizi-Wizsy, N; Passegger, CA; Nebel, L; Krismer, F; Herzer-Schneidhofer, G; Schwach, G; Pfragner, R.
The avian chorioallantoic membrane as an alternative tool to study medullary thyroid cancer.
Endocr Connect. 2019; 8(5):462-467
Doi: 10.1530/EC-18-0431
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- Führende Autor*innen der Med Uni Graz
- Ghaffari Tabrizi-Wizsy Nassim
- Passegger Christina Angelika
- Co-Autor*innen der Med Uni Graz
- Pfragner Roswitha
- Schwach Gert
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- Abstract:
- Preclinical trials of medullary thyroid cancer (MTC) therapeutics require both in vitro and in vivo analyses. Human tumour xenografted rodent models, which are considered the 'gold standard' to study and validate the efficacy and toxicity of lead compounds before translation to clinical trials, are very expensive, subject to organismal variability and ethical controversies. The avian chorioallantoic membrane (CAM) assay provides an alternative versatile, cost-effective and ethically less objectionable short-term, in vivo model for reliable screening of drugs. In this work, we grafted two MTC cell lines and patient-derived MTC tumour samples onto the avian CAM and characterised the resulted tumours histologically and immunohistochemically. Our findings provide the evidence that the CAM assay is a suitable model for studying the pathophysiology of MTC and can even be used as in vivo system for drug testing.
- Find related publications in this database (Keywords)
- medullary thyroid carcinoma
- endocrine cancers
- precilinal trials
- 3R