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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Pizzini, A; Kurz, K; Orth-Hoeller, D; Fille, M; Rabensteiner, J; Lunger, F; Lunger, L; Tschurtschenthaler, C; Tancevski, I; Krause, R; Lass-Floerl, C; Weiss, G; Bellmann-Weiler, R.
The impact of bacteremia on lipoprotein concentrations and patient's outcome: a retrospective analysis.
Eur J Clin Microbiol Infect Dis. 2019; 38(7): 1279-1286. Doi: 10.1007/s10096-019-03543-w [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

Co-Autor*innen der Med Uni Graz: Krause Robert; Rabensteiner Jasmin
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Abstract:: Bacteremia is a major clinical challenge requiring early treatment. Metabolic alterations occur during bacteremia, and accordingly plasma concentrations of lipoproteins LDL-C and HDL-C are substantially changed. We questioned whether bacteremia with Gram-negative versus Gram-positive bacteria causes contrasting changes of lipoprotein levels in order to differentiate between the 2-g stain types and if there is a relation with outcome parameters namely ICU-admission, 30-day mortality, duration of hospitalization. This is a retrospective dual-center cross-sectional study, including 258 patients with bacteremia. Plasma lipid levels were analyzed within 48 h to positive blood culture. Upon admission, HDL-C, LDL-C, and total cholesterol (p = 0.99) in plasma did not significantly differ between patients with Gram-negative and Gram-positive bacteremia, while significantly higher triglyceride concentrations were found in Gram-negative bacteremia (p < 0.05). 30-day mortality and ICU admission were associated with lower LDL-C and HDL-C concentrations as compared to survivors and non-ICU patients, and patients with HDL-C < 20 mg dl^-1 and LDL-C < 55 mg dl^-1 had a relative risk (RR) of 2.85 for ICU therapy requirement and RR = 2 of death within 30 days. Reduced HDL-C and LDL-C concentrations were associated with adverse patient's outcome in bacteremia. Discrimination between Gram-negative and Gram-positive pathogens upon lipoprotein patterns is unlikely.
Find related publications in this database (Keywords): Lipoprotein; HDL; LDL; Triglycerides; Bacteremia; Gram species