Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Ursem, S; Francic, V; Keppel, M; Schwetz, V; Trummer, C; Pandis, M; Aberer, F; Grübler, MR; Verheyen, ND; März, W; Tomaschitz, A; Pilz, S; Obermayer-Pietsch, B; Heijboer, AC.
The effect of vitamin D supplementation on plasma non-oxidised PTH in a randomised clinical trial.
Endocr Connect. 2019; 8(5):518-527
Doi: 10.1530/EC-19-0097
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- Co-Autor*innen der Med Uni Graz
- Aberer Felix
- Francic Vito
- Grübler Martin
- Keppel Martin Helmut
- März Winfried
- Obermayer-Pietsch Barbara
- Pandis Marlene
- Pilz Stefan
- Theiler-Schwetz Verena
- Tomaschitz Andreas
- Trummer Christian
- Verheyen Nicolas Dominik
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- Abstract:
- OBJECTIVE: PTH can be oxidised in vivo, rendering it biologically inactive. Non-oxidised PTH (n-oxPTH) may therefore give a better image of the hormonal status of the patient. While vitamin D supplementation decreases total PTH (tPTH) concentration, the effect on n-oxPTH concentration is unexplored. We investigated the effect of vitamin D on n-oxPTH concentration in comparison to tPTH and compared the correlations between parameters of calcium, bone and lipid metabolism with n-oxPTH and tPTH. METHODS: N-oxPTH was measured in 108 vitamin D-insufficient (25(OH)D <75 nmol/L) hypertensive patients, treated with vitamin D (2800 IE daily) or placebo for 8 weeks in the Styrian Vitamin D Hypertension Trial (NCT02136771). We calculated the treatment effect and performed correlation analyses of n-oxPTH and tPTH with parameters of calcium, bone and lipid metabolism and oxidative stress. RESULTS: After treatment, compared to placebo, 25(OH)D concentrations increased, tPTH decreased by 9% (P < 0.001), n-oxPTH by 7% (P = 0.025) and the ratio of n-oxPTH/tPTH increased (P = 0.027). Changes in phosphate and HDL concentration correlated with changes in n-oxPTH, but not tPTH. CONCLUSIONS: tPTH and n-oxPTH decrease upon vitamin D supplementation. Our study suggests that vitamin D supplementation reduces the oxidation of PTH, as we observed a small but significant increase in the non-oxidised proportion of PTH upon treatment. In addition, we found that changes in phosphate and HDL concentration showed a relationship with changes in n-oxPTH, but not tPTH. This may be explained by the biological activity of n-oxPTH. Further research should be carried out to establish the clinical relevance of n-oxPTH.
- Find related publications in this database (Keywords)
- biochemical markers of bone turnover
- parathyroid hormone
- non-oxidised PTH
- randomised clinical trial
- vitamin D