Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Kaltenborn, A; Hartmann, C; Salinas, R; Ramackers, W; Kleine, M; Vondran, FW; Barthold, M; Lehner, F; Klempnauer, J; Schrem, H.
Risk factors for short- and long-term mortality in liver transplant recipients with MELD score ≥30.
Ann Transplant. 2015; 20(3): 59-69.
Doi: 10.12659/AOT.892322
Web of Science
PubMed
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- Co-authors Med Uni Graz
- Schrem Harald Heinrich
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- Abstract:
- After introduction of MELD-based allocation in Germany, decreased waiting list mortality and increased mortality after transplantation have been reported. This study compares relevant outcome parameters in patients with high MELD ≥30 versus lower MELD scores in a retrospective analysis including 454 consecutively performed liver transplantations in adults (age >16 years) at Hannover Medical School between 01/01/2007 and 31/12/2012 and a follow-up until 31/12/2013. Multivariable risk-adjusted models were applied to identify independent risk factors for 90-day and long-term mortality. MELD score ≥30 (n=117; 26.1%) was an independent risk factor for 90-day mortality (p=0.004, odds ratio: 3.045, 95% CI 1.439-6.498) and long-term mortality (p=0.016, hazard ratio: 1.620, 95% CI 1.095-2.396) and was associated with significantly longer hospital and intensive care unit stays (p<0.001), and death occurred in more cases earlier after transplantation (90-day mortality 21.6% vs. 13.0%; p=0.029). Portal vein thrombosis at transplantation was significantly associated with 90-day mortality after transplantation in patients with MELD scores ≥30 (p=0.041), but this was not the case for patients with MELD scores <30, although portal vein thrombosis was equally frequent in individuals of both groups (3.0% vs. 3.4%, p=0.824). Results of this study suggest that liver transplant recipients with portal vein thrombosis at transplantation should be transplanted before reaching a MELD score ≥30.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Aged -
- Female -
- Female -
- Humans -
- Liver Diseases - surgery
- Liver Transplantation - mortality
- Male -
- Middle Aged -
- Retrospective Studies -
- Risk Factors -
- Transplant Recipients -
- Waiting Lists -
- Young Adult -
- Find related publications in this database (Keywords)
- Aftercare
- Follow-Up Studies
- Liver Transplantation
- Multivariate Analysis
- Postoperative Complications