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Poehnert, D; Grethe, L; Maegel, L; Jonigk, D; Lippmann, T; Kaltenborn, A; Schrem, H; Klempnauer, J; Winny, M.
Evaluation of the Effectiveness of Peritoneal Adhesion Prevention Devices in a Rat Model.
Int J Med Sci. 2016; 13(7): 524-532. Doi: 10.7150/ijms.15167 [OPEN ACCESS]
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Co-authors Med Uni Graz: Schrem Harald Heinrich
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Abstract:: Abdominal operations are followed by adhesions, a prevalent cause of abdominal pain, and the most frequent cause for bowel obstruction and secondary female infertility. This rat study addresses adhesion prevention capability of Adept(®), Interceed(®), Seprafilm(®), and a novel device, 4DryField(®) PH which is provided as powder and generates its effect as gel. Sixty-eight male Lewis rats had cecal abrasion and creation of an equally sized abdominal wall defect, and were grouped randomly: A control group without treatment (n=10); two groups treated with 4DryField(®) PH using premixed gel (n=15) or in-situ gel technique (n=16); one group each was treated with Seprafilm(®) (n=8), Interceed(®) (n=9), or Adept(®) (n=10). Sacrifice was on day 7 to evaluate incidence, quality, and quantity of adhesions, as expressed via adhesion reduction rate (AR). Histologic specimens were evaluated. Statistical analyses used ANOVA and unpaired t-tests. 4DryField(®) PH significantly reduced incidence and severity of adhesions both as premixed gel (AR: 85.2%) and as in-situ made gel (AR: 100%), a comparison between these two application techniques showed no differences in efficacy. Seprafilm(®) did not reduce incidence but severity of adhesions significantly (AR: 53.5%). With Interceed(®) (AR: 3.7%) and Adept(®) (AR: 16.1%) no significant adhesion-reduction was achieved. Except for inflammatory response with Interceed(®), histopathology showed good tissue compatibility of all other devices. 4DryField(®) PH and Seprafilm(®) showed significant adhesion prevention capabilities. 4DryField(®) PH achieved the highest adhesion prevention effectiveness without restrictions concerning mode of application and compatibility and, thus, is a promising strategy to prevent abdominal adhesions.
Find related publications in this database (using NLM MeSH Indexing): Animals -; Carboxymethylcellulose Sodium - therapeutic use; Hyaluronic Acid - therapeutic use; Male -; Membranes, Artificial -; Peritoneal Diseases - prevention & control; Postoperative Complications - prevention & control; Random Allocation -; Rats -; Rats, Inbred Lew -; Tissue Adhesions - prevention & control
Find related publications in this database (Keywords): Adhesion prevention; abdominal surgery; rat model OPAM; 4DryField (R) PH; Adept (R); Interceed (R); Seprafilm (R)