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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Kulik, U; Schrem, H; Bektas, H; Klempnauer, J; Lehner, F.
Prognostic relevance of hematological profile before resection for colorectal liver metastases.
J Surg Res. 2016; 206(2): 498-506.
Doi: 10.1016/j.jss.2016.08.012
Web of Science
PubMed
FullText
FullText_MUG
- Co-authors Med Uni Graz
- Schrem Harald Heinrich
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- Abstract:
- Although alterations of hematological profile and especially elevated platelet counts were reported to influence survival in primary colorectal cancer, its prognostic relevance before the surgical treatment of colorectal liver metastases (CLM) is mainly unclear. Therefore, the aim of this study was to analyze the impact of these factors on overall survival following liver resection of CLM. The surgical treatment of primary CLM between 1994 and 2012 in 983 patients was retrospectively analyzed using univariable and multivariable Cox regression models. In the multivariable analyses, a preoperative anemia was independently associated with inferior overall outcome (P = 0.005, hazard ratio: 1.355). However, with only 2.7% of all cases, an elevation of preoperative platelets was not a frequent finding and no independent impact on survival (P = 0.834). Furthermore, abnormal hemoglobin and platelet values had no impact on rate of surgical revisions due to bleeding complications (P = 0.962 and P = 0.671, respectively), but a potential interaction between abnormal hemoglobin and platelet values and the amount of transfused packed red blood cells (P = 0.004 and P < 0.001, respectively) was observed. Preoperative anemia is statistically significantly associated with inferior overall survival following resection of CLM and might define a new prognostic marker. Preoperative elevated platelets were not a frequent finding and showed no influence on overall survival. Copyright © 2016 Elsevier Inc. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Aged, 80 and over -
- Anemia - blood
- Anemia - complications
- Anemia - diagnosis
- Biomarkers - blood
- Blood Platelets - metabolism
- Colorectal Neoplasms - pathology
- Female -
- Follow-Up Studies -
- Hemoglobins - metabolism
- Hepatectomy - mortality
- Humans -
- Kaplan-Meier Estimate -
- Liver Neoplasms - blood
- Liver Neoplasms - mortality
- Liver Neoplasms - secondary
- Liver Neoplasms - surgery
- Male -
- Middle Aged -
- Platelet Count -
- Preoperative Period -
- Prognosis -
- Proportional Hazards Models -
- Retrospective Studies -
- Risk Factors -
- Survival Rate -
- Thrombocytosis - blood
- Thrombocytosis - complications
- Thrombocytosis - diagnosis
- Treatment Outcome -
- Find related publications in this database (Keywords)
- Colorectal liver metastases
- Mortality
- Risk-adjusted analysis
- Multivariable regression
- Risk factors for survival