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SHR Neuro Cancer Cardio Lipid Metab Microb

Schrem, H; Klempnauer, J; Borlak, J.
Liver-enriched transcription factors in liver function and development. Part II: the C/EBPs and D site-binding protein in cell cycle control, carcinogenesis, circadian gene regulation, liver regeneration, apoptosis, and liver-specific gene regulation.
Pharmacol Rev. 2004; 56(2): 291-330. Doi: 10.1124/pr.56.2.5
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Leading authors Med Uni Graz: Schrem Harald Heinrich
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Abstract:: In the first part of our review (see Pharmacol Rev 2002;54:129-158), we discussed the basic principles of gene transcription and the complex interactions within the network of hepatocyte nuclear factors, coactivators, ligands, and corepressors in targeted liver-specific gene expression. Now we summarize the role of basic region/leucine zipper protein family members and particularly the albumin D site-binding protein (DBP) and the CAAT/enhancer-binding proteins (C/EBPs) for their importance in liver-specific gene expression and their role in liver function and development. Specifically, regulatory networks and molecular interactions were examined in detail, and the experimental findings summarized in this review point to pivotal roles of DBP and C/EBPs in cell cycle control, carcinogenesis, circadian gene regulation, liver regeneration, apoptosis, and liver-specific gene regulation. These regulatory proteins are therefore of great importance in liver physiology, liver disease, and liver development. Furthermore, interpretation of the vast data generated by novel genomic platform technologies requires a thorough understanding of regulatory networks and particularly the hierarchies that govern transcription and translation of proteins as well as intracellular protein modifications. Thus, this review aims to stimulate discussions on directions of future research and particularly the identification of molecular targets for pharmacological intervention of liver disease.
Find related publications in this database (using NLM MeSH Indexing): Animals -; Apoptosis -; CCAAT-Binding Factor - genetics; CCAAT-Binding Factor - metabolism; CCAAT-Binding Factor - physiology; CCAAT-Enhancer-Binding Proteins - genetics; CCAAT-Enhancer-Binding Proteins - metabolism; CCAAT-Enhancer-Binding Proteins - physiology; Cell Cycle - genetics; Cell Cycle - physiology; Circadian Rhythm - genetics; Circadian Rhythm - physiology; DNA-Binding Proteins - genetics; DNA-Binding Proteins - physiology; Gene Expression Regulation - physiology; Humans -; Liver - growth & development; Liver - metabolism; Liver - physiology; Liver Neoplasms - genetics; Liver Neoplasms - metabolism; Liver Regeneration - genetics; Liver Regeneration - physiology; Transcription Factors - genetics; Transcription Factors - metabolism; Transcription Factors - physiology