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SHR Neuro Cancer Cardio Lipid Metab Microb
Kaltenborn, A; Reichert, B; Bourg, CM; Becker, T; Lehner, F; Klempnauer, J; Schrem, H.
Long-term outcome analysis of liver transplantation for severe hepatic trauma.
J Trauma Acute Care Surg. 2013; 75(5): 864-869.
Doi: 10.1097/TA.0b013e3182a8fe8a
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- Co-authors Med Uni Graz
- Schrem Harald Heinrich
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- Abstract:
- Liver transplantation (LTX) for severe hepatic trauma and its sequelae is a rare but potentially lifesaving option at the far end of the operative spectrum. This study analyzes 12 cases with LTX for hepatic trauma and its consequences from two transplant centers. A total of 2,701 consecutive liver transplants unrelated to trauma served as a control group. χ and Mann-Whitney U-tests, Kaplan-Meier analysis with log-rank tests, and Cox regression analysis were applied. Addressed were issues before, during, and after LTX. Major study end points were patient and graft survival. The posttrauma transplant recipients are significantly younger (p = 0.014), with a significantly shorter graft survival (p = 0.038), resulting in a significantly higher retransplantation rate (p = 0.043). Of the 12 patients, 11 underwent surgical treatment for hepatic trauma before LTX with 7 of 12 patients experiencing liver necrosis at the time of LTX. Short-term survival and long-term survival are not significantly different between trauma and nontrauma patients. Severity of liver trauma (Moore Score) and concomitant injuries (Injury Severity Score [ISS]) have no significant impact on patient and graft survival. Four patients with hepatic trauma were treated with two-stage LTX with anhepatic phases between 14 hours and 28 hours. Two of those patients reached long-term survival (20-22 years). LTX for severe liver trauma and its consequences seems justified in extreme cases. The high frequency of liver necrosis at the time of LTX may indicate possible shortcomings in liver packing technique or liver resection for hemorrhage control. Thus, severe hepatic trauma requires treatment by experienced liver surgeons and emergency physicians. Therapeutic study, level IV.
- Find related publications in this database (using NLM MeSH Indexing)
- Abdominal Injuries - diagnosis
- Abdominal Injuries - mortality
- Abdominal Injuries - surgery
- Adolescent -
- Adult -
- Child -
- Female -
- Follow-Up Studies -
- Forecasting -
- Forecasting -
- Hepatectomy - methods
- Humans -
- Kaplan-Meier Estimate -
- Liver - injuries
- Liver - surgery
- Liver Transplantation - methods
- Liver Transplantation - mortality
- Male -
- Middle Aged -
- Reoperation -
- Survival Rate - trends
- Time Factors -
- Trauma Severity Indices -
- Young Adult -
- Find related publications in this database (Keywords)
- Liver trauma
- two-stage procedure
- anhepatic phase
- abdominal injury
- operative management