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Selected Publication:
Vogl, TJ; Hammerstingl, R; Schwarz, W; Kümmel, S; Müller, PK; Balzer, T; Lauten, MJ; Balzer, JO; Mack, MG; Schimpfky, C; Schrem, H; Bechstein, WO; Neuhaus, P; Felix, R.
Magnetic resonance imaging of focal liver lesions. Comparison of the superparamagnetic iron oxide resovist versus gadolinium-DTPA in the same patient.
Invest Radiol. 1996; 31(11):696-708
Doi: 10.1097/00004424-199611000-00004
Web of Science
PubMed
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FullText_MUG
- Co-authors Med Uni Graz
- Schrem Harald Heinrich
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- Abstract:
- The authors assess the efficacy of static and dynamic magnetic resonance (MR) imaging using the superparamagnetic iron oxide SHU-555A (Resovist) versus standard dose of gadolinium (Gd)-DTPA in patients with focal liver lesions. Magnetic resonance imaging was performed in 30 patients suffering from histopathologically verified malignant (n = 22) and benign (n = 8) liver lesions. T2-weighted conventional and fat-suppressed as well as T1-weighted sequences were used before, during, and after fast intravenous administration of Resovist (1 mL/minute) at three doses of 4, 8, and 16 mumol/kg body weight. One week before the Resovist-enhanced MR imaging study 20 patients underwent Gd-DTPA-enhanced MR imaging. Detection rate was improved for metastatic lesions revealing 36 lesions unenhanced versus 53 focal lesions using Resovist-enhanced MR imaging. Gadolinium-DTPA-enhanced scans showed no additional lesion versus unenhanced and Resovist-enhanced MR imaging. Static and dynamic imaging demonstrated no measurable percentage signal intensity loss (PSIL) using Resovist-enhanced MR imaging versus a percentage enhancement of 79.7% in Gd-DTPA enhanced scans. In the dynamic T2-weighted sequences, hepatocellular carcinoma nodules (n = 4) showed a rapid decrease in signal intensity starting at 44 seconds. Postinfusion of Resovist followed by a low, constant increase in signal intensity. Gadolinium-DTPA enhanced scans showed a percentage enhancement of 73.4 focal nodular hyperplasia (FNH) and hemangioma revealed a strong and early dose-dependent PSIL 44 to 60 seconds postinfusion with a prolonged signal loss for the FNH in the late study. Statistical evaluation revealed a statistically significant superiority of Resovist-enhanced MR imaging concerning the detection and delineation of focal liver lesions compared with unenhanced and Gd-DTPA enhanced scans (P < 0.05). The fast infusion of the new superparamagnetic contrast agent Resovist shows advantages for dynamic and static MR imaging of focal liver lesions.
- Find related publications in this database (using NLM MeSH Indexing)
- Carcinoma, Hepatocellular - diagnosis
- Contrast Media -
- Dextrans -
- Ferrosoferric Oxide -
- Follow-Up Studies -
- Gadolinium -
- Gadolinium DTPA -
- Hemangioma - diagnosis
- Humans -
- Iron -
- Liver Diseases - diagnosis
- Liver Neoplasms - diagnosis
- Magnetic Resonance Imaging - methods
- Magnetite Nanoparticles -
- Organometallic Compounds -
- Oxides -
- Pentetic Acid - analogs & derivatives
- Prospective Studies -
- Suspensions -
- Find related publications in this database (Keywords)
- magnetic resonance imaging
- liver tumor
- contrast media
- superparamagnetic iron oxide
- human