Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Bektas, H; Schrem, H; Lehner, F; Lueck, R; Becker, T; Musholt, T; Klempnauer, J.
Blood transfers infectious immunologic tolerance in MHC-incompatible heart transplantation in rats.
J Heart Lung Transplant. 2005; 24(5): 614-617.
Doi: 10.1016/j.healun.2004.01.016
Web of Science
PubMed
FullText
FullText_MUG
- Co-authors Med Uni Graz
- Schrem Harald Heinrich
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- "Infectious tolerance" or inducing immunologic tolerance of infection in allografts is still poorly understood. We investigated whether transfusing blood from LEW.1A rats tolerant of LEW.1W hearts could transmit tolerance to naive LEW.1A rats. In 4 of 6 cases, transfusing blood from tolerant animals was followed by immunologic tolerance of heart transplants from LEW.1W donor rats in LEW.1A recipient animals, whereas transplanting heart grafts that were tolerated in previous transplantations across MHC barriers did not transfer tolerance in major histocompatibility complex (MHC)-incompatible animals. We conclude that in rat heart transplantation, the transfer of immunologic tolerance can be enhanced by transfusing blood from tolerant animals to naive animals before transplantation across MHC barriers.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Blood Transfusion -
- Graft Rejection - immunology
- Graft Survival - immunology
- Heart Transplantation - immunology
- Immune Tolerance - immunology
- Major Histocompatibility Complex - immunology
- Models, Animal -
- Preoperative Care -
- Rats -
- Rats, Inbred Lew -
- Transplantation Immunology - immunology
- Transplantation Tolerance - immunology