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SHR Neuro Cancer Cardio Lipid Metab Microb
Zachau, L; Zeckey, C; Schlue, J; Sander, J; Meyer-Heithuis, C; Winkler, M; Klempnauer, J; Schrem, H.
Haematogenous abdominal wall metastasis of differentiated, alpha-fetoprotein-negative hepatocellular carcinoma after previous antiandrogen therapy within a site of lipoma manifestation since childhood.
World J Surg Oncol. 2012; 10(2): 98-98.
Doi: 10.1186/1477-7819-10-98
(- Case Report)
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- Leading authors Med Uni Graz
- Schrem Harald Heinrich
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- Abstract:
- Cases with subcutaneous metastasis of differentiated hepatocellular carcinoma to the abdominal wall without prior seeding as a consequence of local interventions with a negative or normal alpha-fetoprotein level in the serum are extremely rare. This is the first report of a case with AFP-negative, differentiated hepatocellular carcinoma metastasis to the abdominal wall within a pre-existing subcutaneous lipoma since childhood after antiandrogen therapy with leuprorelin and buserelin acetate for prostate cancer without seeding. Clinical features including histology, immunohistochemistry, clinical course and surgical approach are presented. Histological examination revealed a hepatocellular carcinoma with a trabecular and pseudoglandular growth pattern with moderately atypical hepatocytes with multifocal bile formation within a lipoma. The postoperative course of abdominal wall reconstruction with a monocryl-prolene mesh and a local flap after potentially curative resection was uncomplicated. It may be that previous antiandrogen treatment for prostate carcinoma contributed to the fact that our patient developed alpha-fetoprotein-negative and androgen receptor-negative subcutaneous abdominal wall metastasis within a pre-existing lipoma since childhood.
- Find related publications in this database (using NLM MeSH Indexing)
- Abdominal Neoplasms - chemically induced
- Abdominal Neoplasms - metabolism
- Abdominal Neoplasms - secondary
- Abdominal Neoplasms - surgery
- Abdominal Wall - pathology
- Abdominal Wall - surgery
- Aged -
- Androgen Antagonists - adverse effects
- Carcinoma, Hepatocellular - chemically induced
- Carcinoma, Hepatocellular - metabolism
- Carcinoma, Hepatocellular - pathology
- Carcinoma, Hepatocellular - surgery
- Cell Differentiation -
- Child -
- Humans -
- Lipoma - chemically induced
- Lipoma - pathology
- Lipoma - surgery
- Liver Neoplasms - chemically induced
- Liver Neoplasms - metabolism
- Liver Neoplasms - pathology
- Liver Neoplasms - surgery
- Male -
- Neoplasm Staging -
- Prognosis -
- Prostatic Neoplasms - drug therapy
- alpha-Fetoproteins - metabolism
- Find related publications in this database (Keywords)
- Hepatocellular carcinoma
- Cutaneous metastasis
- Antiandrogen therapy