Medizinische Universität Graz - Research portal
Selected Publication:
Haselsberger, K; Radner, H; Gössler, W; Schlagenhaufen, C; Pendl, G.
Subcellular boron-10 localization in glioblastoma for boron neutron capture therapy with Na2B12H11SH.
J NEUROSURG. 1994; 81(5): 741-744.
Doi: 10.3171/jns.1994.81.5.0741
Web of Science
PubMed
FullText
FullText_MUG
- Leading authors Med Uni Graz
- Haselsberger Klaus
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Because of the short range of the highly energetic particles helium-4 and lithium-7 that results from neutron-induced disintegration of boron-10, the efficacy of Boron Neutron Capture Therapy (BNCT) is heavily dependent on 10B-microlocation. Despite the crucial importance of boron-10, there is little specific information with regard to the agent currently used for inducing BNCT, namely Na2B12H11SH. In the present study, a subcellular 10B-location was investigated in tumor tissue obtained from seven patients with glioblastoma World Health Organization Grade IV. These patients received Na2B12H11SH at doses used in therapeutic trials (75 mg/kg body weight in five patients, and 150 mg/kg body weight in two patients, respectively). In three cases, boron-10 was identified in glioblastoma cells by laser microprobe mass analysis. In these tumors, boron-10 was found only in the nuclei of neoplastic cells but not in other cell compartments. These preliminary results suggest a predominant association of Na2B12H11SH with the nuclei of malignant glioma cells and thus support the value of Na2B12H11SH as a suitable boron carrier for BNCT.
- Find related publications in this database (using NLM MeSH Indexing)
- Borohydrides - metabolism
- Boron - metabolism
- Boron Neutron Capture Therapy - metabolism
- Brain Neoplasms - metabolism
- Cell Nucleus - metabolism
- Glioblastoma - metabolism
- Humans - metabolism
- Isotopes - metabolism
- Lasers - metabolism
- Mass Spectrometry - metabolism
- Microscopy, Electron - metabolism
- Signal Processing, Computer-Assisted - metabolism
- Subcellular Fractions - metabolism
- Sulfhydryl Compounds - metabolism
- Find related publications in this database (Keywords)
- Boron Neutron Capture Therapy
- Brain Neoplasm
- Glioblastoma
- Laser Analysis