Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Miehlke, S; Verhaegh, B; Tontini, GE; Madisch, A; Langner, C; Münch, A.
Microscopic colitis: pathophysiology and clinical management.
Lancet Gastroenterol Hepatol. 2019; 4(4): 305-314.
Doi: 10.1016/S2468-1253(19)30048-2
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Langner Cord
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- Abstract:
- Microscopic colitis is a chronic inflammatory disease of the colon that frequently causes chronic watery diarrhoea that might be accompanied by abdominal pain, nocturnal diarrhoea, urgency, and faecal incontinence. These symptoms lead to poor quality of life and increased health-care costs. Diagnosis relies on histological examination of multiple biopsy samples from the colonic mucosa, which often show no or only few abnormalities on endoscopy. Two major histological subtypes can be distinguished-collagenous colitis and lymphocytic colitis-but incomplete and variant forms with fewer characteristic features have been reported. Here we summarise the latest evidence on epidemiology, pathogenesis, and risk factors, and discuss established and novel therapeutic options for clinical remission. Finally, we propose an updated treatment algorithm. Further prospective studies are needed to clarify the natural history of microscopic colitis, supported by validated criteria for the assessment of disease activity. Copyright © 2019 Elsevier Ltd. All rights reserved.