Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Reinehr, T; Karges, B; Meissner, T; Wiegand, S; Fritsch, M; Holl, RW; Woelfle, J.
Fibroblast Growth Factor 21 and Fetuin-A in Obese Adolescents With and Without Type 2 Diabetes.
J Clin Endocrinol Metab. 2015; 100(8): 3004-3010.
Doi: 10.1210/jc.2015-2192
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- Co-Autor*innen der Med Uni Graz
- Fritsch Maria
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- Abstract:
- Hepatokines such as fetuin-A or fibroblast growth factor 21 (FGF21) are reasonable candidates affecting the pathophysiology of type 2 diabetes mellitus (T2DM). However, studies in humans at the onset of disease are scarce. The objective of the study was to compare FGF21 and fetuin-A levels between adolescents with and without T2DM. This was a cross-sectional comparison of adolescents with and without T2DM. The study was conducted at diabetes and obesity treatment centers. Seventy-four predominantly Caucasian adolescents with T2DM aged 12-18 years and 74 body mass index (BMI)-, age-, and gender-matched controls participated in the study. There were no interventions. FGF21 and fetuin-A and their correlation to age, BMI, glycated hemoglobin, blood pressure, lipids, adiponectin, and leptin were measured. Adolescents with T2DM showed significant higher FGF21 serum concentrations compared with obese controls without T2DM [median 277 pg/mL (interquartile range [IQR] 161-586) vs 200 pg/mL (IQR 116-323), respectively, P = .009] and higher fetuin-A serum concentrations (median 0.30 g/L (IQR 0.27-0.33) vs 0.28 g/L (IQR 0.25-0.30), respectively, P = .005). In a multiple linear regression analysis, fetuin-A was positively associated with glycated hemoglobin [β-coefficient 0.005 (95% confidence interval ± 0.004), P = .013], negatively with adiponectin (β-coefficient -0.004 (95% confidence interval ±0.002, P = .006) but not with BMI, age, gender, ethnicity, or leptin. FGF21 was not associated with any parameter in multiple linear regression analysis. Increased FGF21 serum levels in obese adolescents with T2DM compared with obese adolescents without T2DM suggest a FGF21-resistant state in T2DM because FGF21 improves insulin sensitivity. The increase of fetuin-A levels in obese adolescents with T2DM supports the hypothesis that fetuin-A is involved in the pathogenesis of T2DM because this hepatokine leads to insulin resistance.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Blood Glucose - metabolism
- Body Mass Index -
- Case-Control Studies -
- Cross-Sectional Studies -
- Diabetes Mellitus, Type 2 - blood
- Diabetes Mellitus, Type 2 - complications
- Female -
- Fibroblast Growth Factors - blood
- Glycated Hemoglobin A - metabolism
- Humans -
- Male -
- Pediatric Obesity - blood
- Pediatric Obesity - complications
- alpha-2-HS-Glycoprotein - metabolism