Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
de Sousa, G; Prinz, N; Becker, M; Dürr, R; Faller, U; Meraner, D; Heise, N; Engelmann, I; Bruckmayer, H; Wiemann, D; Fritsch, M; Stratmann, B; Holl, RW.
Diabetes Mellitus and Autoimmune Hepatitis: Demographical and Clinical Description of a Relatively Rare Phenotype.
Horm Metab Res. 2018; 50(7): 568-574.
Doi: 10.1055/a-0631-2468
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
- Co-authors Med Uni Graz
- Fritsch Maria
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- We studied demographic, metabolic, and clinical characteristics of patients with diabetes and autoimmune hepatitis (AIH) from the German/Austrian DPV registry. A total of 139 patients with diabetes and AIH were analyzed and compared to 437 728 patients with diabetes without AIH. The prevalence of AIH in patients with T1DM (44.8/100 000) seems higher than in the general population, the prevalence of AIH in patients with T2DM (23.6/100 000) does not seem to be increased. Patients with T2DM and AIH had a shorter duration of diabetes (p=0.007) and a higher proportion of females (p<0.001) compared to T2DM without AIH. Patients with diabetes (T1DM or T2DM) and AIH required higher insulin doses (p<0.001 and p=0.03, respectively) and showed increased liver enzymes (aspartate transaminase, alanine transaminase, gamma-glutamyltransferase) compared to diabetes patients without (all p<0.001). We detected a lower percentage of patients treated with oral antidiabetic drugs (p=0.01) and a higher percentage of patients treated by insulin in patients with T2DM and AIH (p<0.001) compared to patients with T2DM alone. We observed a higher incidence of autoimmune thyroid disease (AIT) in patients with diabetes (T1DM or T2DM) and AIH (p<0.001) compared to diabetes patients without AIH. AIH seems more frequent in patients with T1DM. Patients with diabetes and AIH require intensification of antidiabetic therapy and seem to have a higher prevalence of AIT. © Georg Thieme Verlag KG Stuttgart · New York.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Aged -
- Autoantibodies - blood
- Demography -
- Diabetes Mellitus - drug therapy
- Diabetes Mellitus - epidemiology
- Diabetes Mellitus - physiopathology
- Female -
- Germany - epidemiology
- Hepatitis, Autoimmune - complications
- Hepatitis, Autoimmune - drug therapy
- Hepatitis, Autoimmune - epidemiology
- Humans -
- Hypoglycemic Agents - therapeutic use
- Male -
- Meta-Analysis as Topic -
- Middle Aged -
- Phenotype -
- Prevalence -
- Young Adult -
- Find related publications in this database (Keywords)
- type 1 diabetes
- type 2 diabetes
- autoimmune thyroid disease
- clinical outcome
- diabetes treatment