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Bonfig, W; Kapellen, T; Dost, A; Fritsch, M; Rohrer, T; Wolf, J; Holl, RW; Diabetes Patienten Verlaufsdokumentationssystem Initiative of the German Working Group for Pediatric Diabetology and the German Bundesministerium für Bildung und Forschung Competence Net for Diabetes Mellitus.
Growth in children and adolescents with type 1 diabetes.
J Pediatr. 2012; 160(6): 900-903. Doi: 10.1016/j.jpeds.2011.12.007
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Co-authors Med Uni Graz: Fritsch Maria
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Abstract:: To investigate the effect of type 1 diabetes on growth and adult height. Data from 22 651 children (10 494 females) with type 1 diabetes documented at onset of the disease from specialized centers in Germany and Austria were analyzed. Patients of non-German and non-Austrian origin and patients with celiac disease were excluded from the analysis. Near-adult height data were available in 1685 patients. At the time of diagnosis of type 1 diabetes, the mean age of the 22 651 children was 8.8 ± 4.2 years, with a mean height SDS of 0.22 ± 1.0. The 1685 patients with diabetes onset before age 11 years reached a mean adult height of -0.16 ± 1.0 SDS. Mean adult height was was 167.1 ± 6.2 cm (-0.16 ± 0.97 SDS) in females (n = 846) and 179.6 ± 7.1 cm (-0.17 ± 1.0 SDS) in males (n = 839). Mean duration of diabetes was 9.1 ± 2.6 years, and mean Hemoglobin A1c concentration was 7.9% ± 1.2% (63 ± 10 mmol/mol). In a multivariate regression model, adult height was positively correlated with height at onset of diabetes (P < .0001) and negatively with mean Hemoglobin A1c (P < .0001) and duration of diabetes (P = .0015). Height at the time of diagnosis of type 1 diabetes is above average. Even with intensive insulin therapy, growth and adult height remain indicators of metabolic diabetes control in the 21st century. Copyright © 2012 Mosby, Inc. All rights reserved.
Find related publications in this database (using NLM MeSH Indexing): Adolescent -; Adolescent Development - physiology; Adolescent Development - epidemiology; Body Height -; Body Weight -; Child -; Child Development - physiology; Child, Preschool -; Diabetes Mellitus, Type 1 - epidemiology; Diabetes Mellitus, Type 1 - physiopathology; Female -; Follow-Up Studies -; Follow-Up Studies - epidemiology; Humans -; Incidence -; Infant -; Infant, Newborn -; Male -; Retrospective Studies -