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SHR Neuro Cancer Cardio Lipid Metab Microb
Schlager, O; Widhalm, K; Hammer, A; Giurgea, A; Margeta, C; Fritsch, M; Zehetmayer, S; Koppensteiner, R; Gschwandtner, ME; Willfort-Ehringer, A.
Familial hypercholesterolemia affects microvascular autoregulation in children.
Metabolism. 2013; 62(6): 820-827.
Doi: 10.1016/j.metabol.2012.12.013
Web of Science
PubMed
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- Co-authors Med Uni Graz
- Fritsch Maria
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- Abstract:
- Familial hypercholesterolemia (FH) impairs macrovascular endothelial function in childhood and causes an increase of cardiovascular risk in later life. Whether microvascular function is affected in children with FH is unknown. The aim of this study was to investigate the impact of FH on microvascular autoregulation in children by post occlusive reactive hyperemia (PORH). PORH of the skin was assessed using laser Doppler fluxmetry. Baseline perfusion, biological zero, defined as no-flow laser Doppler signal during suprasystolic occlusion, peak perfusion after release of suprasystolic occlusion, as well as time to peak perfusion and recovery time, defined as time until baseline perfusion is resumed, were measured in 16 children, who were diagnosed with FH according to current guidelines, and in 91 healthy controls. In children with FH, peak perfusion was higher (FH: 1.60±0.68 vs. controls: 1.26±0.50 AU [arbitrary units], p=0.02), recovery time was longer (110±42.61 vs. 83.18±35.08 s, p=0.01) and biological zero was lower than in controls (0.12±0.04 vs. 0.18±0.05 AU, p<0.001). Baseline perfusion and time to peak were not different between children with FH and controls (baseline perfusion: 0.43±0.21 vs. 0.38±0.15 AU, p=0.18; time to peak: 15.44±12.25 vs. 18.18±17.79 s, p=0.56). For the first time the present study reveals an impact of FH on microvascular autoregulation in children: the differences of PORH between children with FH and controls indicate an affected autoregulation of microvascular blood flow in FH, which has its onset in childhood. Copyright © 2013 Elsevier Inc. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Blood Pressure -
- Body Mass Index -
- Case-Control Studies -
- Child -
- Female -
- Homeostasis -
- Humans -
- Hypercholesterolemia - drug therapy
- Hypercholesterolemia - genetics
- Hypercholesterolemia - physiopathology
- Hyperemia - physiopathology
- Hypolipidemic Agents - therapeutic use
- Male -
- Microvessels - physiopathology
- Skin - blood supply
- Find related publications in this database (Keywords)
- Hypercholesterolemia
- Microcirculation
- Pediatric
- Laser Doppler