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SHR Neuro Cancer Cardio Lipid Metab Microb

Weber, KS; Straßburger, K; Fritsch, M; Bierwagen, A; Koliaki, C; Phielix, E; Pacini, G; Hwang, JH; Markgraf, DF; Burkart, V; Müssig, K; Szendroedi, J; Roden, M.
Meal-derived glucagon responses are related to lower hepatic phosphate concentrations in obesity and type 2 diabetes.
Diabetes Metab. 2018; 44(5): 444-448. Doi: 10.1016/j.diabet.2018.05.008 [OPEN ACCESS]
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Co-authors Med Uni Graz: Fritsch Maria
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Abstract:: Type 2 diabetes (T2D) alters glucagon, glucagon-like peptide (GLP)-1, glucose-dependent insulinotropic polypeptide (GIP) and hepatic energy metabolism, yet the possible relationships remain unclear. In this observational study, lean insulin-sensitive control subjects (BMI: 23.2±1.5kg/m²), age-matched insulin-resistant obese subjects (BMI: 34.3±1.7kg/m²) and similarly obese elderly T2D patients (BMI: 32.0±2.4kg/m²) underwent mixed-meal tolerance tests (MMTTs), and assessment of hepatic γATP, inorganic phosphate (P_i) and lipids using ³¹P/¹H magnetic resonance spectroscopy. Meal-induced secretion of glucagon and incretins was calculated from incremental areas under the concentration-time curves (iAUCs). Peripheral and adipose tissue insulin sensitivity were assessed from time courses of circulating glucose, insulin and free fatty acids. MMTT-derived peripheral insulin sensitivity was lowest in T2D patients (P<0.001), while glucagon concentrations were comparable across all three groups. At 260min, GLP-1 was lower in T2D patients than in controls, whereas GIP was lowest in obese individuals. Fasting glucagon concentrations correlated positively with fasting (r=0.60) and postprandial hepatocellular lipid levels (160min: r=0.51, 240min: r=0.59), and negatively with adipose tissue insulin sensitivity (r=-0.73). Higher meal-induced glucagon release (iAUC_0-260_min) correlated with lower fasting (r=-0.62) and postprandial P_i levels (160min: r=-0.43, 240min: r=-0.42; all P<0.05). Higher meal-induced release of GIP (iAUC_0-260_min) correlated positively with fasting (r=0.54) and postprandial serum triglyceride concentrations (iAUC_0-260_min, r=0.54; all P<0.01). Correlations between fasting glucagon and hepatic lipids and between meal-induced glucagon and hepatic P_i suggest a role for glucagon in hepatic energy metabolism. Copyright © 2018 Elsevier Masson SAS. All rights reserved.
Find related publications in this database (Keywords): Adipose tissue; Glucagon; GIP; GLP-1; Hepatic fat content; Insulin sensitivity