Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Schlager, O; Hammer, A; Willfort-Ehringer, A; Fritsch, M; Rami-Merhar, B; Schober, E; Nagl, K; Giurgea, A; Margeta, C; Zehetmayer, S; Schernthaner, GH; Koppensteiner, R; Gschwandtner, ME.
Microvascular autoregulation in children and adolescents with type 1 diabetes mellitus.
Diabetologia. 2012; 55(6): 1633-1640.
Doi: 10.1007/s00125-012-2502-8
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- Co-Autor*innen der Med Uni Graz
- Fritsch Maria
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- Abstract:
- Deterioration of microvascular function may have an early onset in individuals with type 1 diabetes mellitus. We hypothesised that microvascular autoregulation is impaired in children with type 1 diabetes and can be detected non-invasively by postocclusive reactive hyperaemia (PORH). Microvascular autoregulation was assessed in 58 children with type 1 diabetes and 58 age- and sex-matched healthy controls by PORH using laser Doppler fluxmetry. Baseline perfusion, biological zero (defined as a 'no flow' laser Doppler signal during suprasystolic occlusion), peak perfusion following occlusion, time to peak and recovery time (time until baseline perfusion is resumed) were recorded and compared between the groups. Peak perfusion was higher in children with type 1 diabetes than in healthy controls (1.7 ± 0.93 AU [arbitrary units] vs 1.29 ± 0.46 AU; p = 0.004), and biological zero was lower in children with type 1 diabetes vs controls (0.14 ± 0.04 AU vs 0.19 ± 0.04 AU; p < 0.0001). No differences were seen between the groups in baseline perfusion, time to peak during PORH and recovery time following PORH. PORH reveals impaired microvascular autoregulation in children with type 1 diabetes. The higher peak perfusion might reflect a decline in the vasoconstrictive ability of arteriolar smooth muscle cells upstream of capillary beds in children with type 1 diabetes.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Case-Control Studies -
- Child -
- Diabetes Mellitus, Type 1 - physiopathology
- Female -
- Homeostasis - physiology
- Humans -
- Laser-Doppler Flowmetry -
- Male -
- Microcirculation - physiology
- Find related publications in this database (Keywords)
- Autoregulation
- Children
- Laser Doppler
- Microcirculation
- Type 1 diabetes mellitus