Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Fritsch, M; Rosenbauer, J; Schober, E; Neu, A; Placzek, K; Holl, RW; German Competence Network Diabetes Mellitus and the DPV Initiative.
Predictors of diabetic ketoacidosis in children and adolescents with type 1 diabetes. Experience from a large multicentre database.
Pediatr Diabetes. 2011; 12(4 Pt 1): 307-312.
Doi: 10.1111/j.1399-5448.2010.00728.x
Web of Science
PubMed
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FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Fritsch Maria
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- Abstract:
- Diabetic ketoacidosis (DKA) remains a major cause of hospitalization and death in children and adolescents with established type 1 diabetes despite DKA preventing strategies. The aim of the study was to determine incidence and risk factors for DKA in a large cohort of young diabetic patients. This investigation uses the dpv-wiss base containing data on 28 770 patients with type 1 diabetes <20yr, from Germany and Austria. For each patient the most recent year of follow-up was evaluated. DKA was defined as pH < 7.3 and/or hospital admission as a result of DKA, excluding onset DKA. Mean age of the study cohort was 13.96 ± 4.0 yr (47.9% females). A total of 94.1% presented with no episode, 4.9% with 1 episode, and 1.0% with recurrent DKA (≥2). When comparing these three groups, age (p < 0.01), HbA1c (p < 0.01), and insulin dose (p < 0.01) were significantly higher in patients with recurre nt DKA. Incidence of DKA was significantly higher in females (7.3 ± 0.5 vs. 5.8 ± 0.2; p = 0.03) and in patients with migration background (7.8 ± 0.6 vs. 6.3 ± 0.3; p = 0.02). No significant association was found with treatment type and diabetes duration. In a cohort of European paediatric diabetic patients, the rate of DKA was significantly higher in females and in children with migration background and early teenage years. © 2011 John Wiley & Sons A/S.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Age Factors -
- Age of Onset -
- Austria - epidemiology
- Child -
- Diabetes Mellitus, Type 1 - drug therapy
- Diabetes Mellitus, Type 1 - epidemiology
- Diabetic Ketoacidosis - epidemiology
- Emigration and Immigration -
- Female -
- Germany - epidemiology
- Glycated Hemoglobin A - metabolism
- Humans -
- Incidence -
- Insulin - therapeutic use
- Male -
- Find related publications in this database (Keywords)
- acute complications
- BMI
- BMI-SDS
- CE
- childhood
- CSII
- CT
- DCCT
- diabetic ketoacidosis
- DKA
- DPV
- MDI
- MOM
- SD
- SEM
- type 1 diabetes