Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Giurgea, GA; Nagl, K; Gschwandtner, M; Höbaus, C; Hörtenhuber, T; Koppensteiner, R; Margeta, C; Fritsch, M; Rami-Merhar, B; Schernthaner, GH; Schlager, O; Schober, E; Steiner, S; Willfort-Ehringer, A.
Gender, metabolic control and carotid intima-media-thickness in children and adolescents with type 1 diabetes mellitus.
Wien Klin Wochenschr. 2015; 127(3-4): 116-123.
Doi: 10.1007/s00508-014-0640-3
Web of Science
PubMed
FullText
FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Fritsch Maria
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Despite a marked improvement in the overall prognosis of patients with type 1 diabetes mellitus (T1DM), cardiovascular morbidity/mortality is still increased. Since cellular and microvascular aberrations have been demonstrated already in children with T1DM, albeit a good glycemic control (CO), we hypothesized that early macrovascular changes can be detected by common carotid artery intima-media thickness (CCA-IMT). We included 73 children/adolescents with T1DM (34 boys, 39 girls; mean age, 14.8 ± 2 years) and 243 sex- and age-matched healthy CO. In T1DM mean HbA1c was 7.9 ± 1.1 rel.%, and duration of disease 7.5 ± 3.1 years. High-resolution ultrasonography was used to assess CCA-IMT, defined as the mean of 24 measurements of the near and far wall on both right and left CCA. CCA-IMT was not different in the total of children and adolescents with T1DM compared with CO (0.302 ± 0.057 vs. 0.301 ± 0.054 mm; p = 0.88). Analysis according to gender, however, revealed higher CCA-IMT values in girls than in boys in the diabetic cohort (0.315 ± 0.055 vs. 0.288 ± 0.058 mm; p = 0.047), whereas CCA-IMT was higher in boys than in girls in the CO group (0.321 ± 0.057 vs. 0.284 ± 0.045 mm; p < 0.001). Multiple stepwise backward regression showed that in the T1DM group only HbA1c remained significantly associated with CCA-IMT (Beta = - 0.307, p = 0.008). In CO, gender (Beta = - 0.302, p < 0.001), body mass index (Beta = 0.226, p < 0.001) and systolic blood pressure (Beta = 0.213, p < 0.001) were predictive of CCA-IMT. Our data suggest that in children/adolescents with T1DM the quality of metabolic CO (HbA1c) is the most important predictor of CCA-IMT and outweighs the effect of gender.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Age Distribution -
- Atherosclerosis - diagnostic imaging
- Atherosclerosis - epidemiology
- Austria - epidemiology
- Carotid Intima-Media Thickness - statistics & numerical data
- Causality -
- Comorbidity -
- Diabetes Mellitus, Type 1 - diagnosis
- Diabetes Mellitus, Type 1 - drug therapy
- Diabetes Mellitus, Type 1 - epidemiology
- Humans -
- Incidence -
- Reproducibility of Results -
- Risk Factors -
- Sensitivity and Specificity -
- Sex Distribution -
- Treatment Outcome -
- Find related publications in this database (Keywords)
- Children
- Type 1 diabetes mellitus
- Intima-media-thickness
- Macrovascular
- Ultrasound