Medizinische Universität Graz - Research portal

Go directly to the nagivation.
Go directly to the content.

Navigation/Search

Selected Publication:

SHR Neuro Cancer Cardio Lipid Metab Microb

Rack, B; Zombirt, E; Trapp, E; Jückstock, J; Andergassen, U; Neugebauer, J; Kost, B; Weissenbacher, T; Jeschke, U; Schindlbeck, C; Janni, W; Alunni-Fabbroni, M.
Comparison of HER2 Expression in Primary Tumor and Disseminated Tumor Cells in the Bone Marrow of Breast Cancer Patients.
Oncology. 2016; 90(4):232-238 Doi: 10.1159/000442986 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

Co-authors Med Uni Graz: Trapp Elisabeth Katharina
Altmetrics:
Dimensions Citations:
Plum Analytics:
Scite (citation analytics):
Abstract:: The aim of this study was to measure the human epidermal growth factor receptor 2 (HER2) status of disseminated tumor cells (DTCs) from bone marrow (BM) aspirates and to assess correspondence or discrepancy with the primary tumor. DTCs were isolated from the BM of 156 breast cancer patients. Cytokeratin-positive DTCs were further analyzed by the chromogenic in situ hybridization method to detect HER2 gene amplification. A significant correlation (p = 0.021) was found between the HER2 status of DTCs and the primary tumors. Sixty-one (68.5%) patients had a corresponding status. However, a shift of phenotype between primary tumor and DTCs was found in the remaining patients. This study showed a significant grade of discordance of the HER2 status between primary tumors and DTCs in the BM of a relevant subgroup of patients. Detection of HER2 amplification on DTCs could therefore help to better stratify patients for a more tailored therapy, since they would benefit from a HER2-targeted therapy. © 2016 S. Karger AG, Basel.
Find related publications in this database (using NLM MeSH Indexing): Adult -; Aged -; Aged, 80 and over -; Biomarkers, Tumor - genetics; Bone Marrow - pathology; Bone Marrow Cells - pathology; Breast Neoplasms - genetics; Breast Neoplasms - pathology; Female -; Humans -; Middle Aged -; Neoplasm, Residual -; Neoplastic Cells, Circulating - pathology; Prognosis -; Receptor, ErbB-2 - biosynthesis; Receptor, ErbB-2 - genetics
Find related publications in this database (Keywords): Breast cancer; Circulating tumor cells; Disseminated tumor cells; Minimal residual disease; HER2; Bone marrow; HER2-targeting agent