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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Villar, V; Kocic, J; Bugarski, D; Jovcic, G; Santibanez, JF.
SKIP is required for TGF-β1-induced epithelial mesenchymal transition and migration in transformed keratinocytes.
FEBS Lett. 2010; 584(22):4586-4592
Doi: 10.1016/j.febslet.2010.10.020
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- Co-authors Med Uni Graz
- Krstic Jelena
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- Abstract:
- Transforming growth factor-β1 (TGF-β1) potently induces the epithelial-mesenchymal transition (EMT) during tumoral progression. Although Sky-interacting protein (SKIP) regulates TGF-β1-induced Smad activation, its role in the induction of cell malignance remains uncertain. We found that TGF-β1 increases SKIP expression in PDV cells. In cells stably transfected with SKIP antisense, AS-S, Smad3 activation decreased, along with an inhibition of TGF-β1-induced EMT, and the cells were sensitized to the TGF-β1-dependent inhibition of proliferation. Also, AS-S cells showed a weaker migration and invasion response. Moreover, TGF-β1-induced urokinase-type plasminogen activator expression was inhibited, concomitantly with a TGF-β1-independent increment of the plasminogen-activator inhibitor-1 expression. Thus, these results suggest that SKIP is required for EMT and invasiveness induced by TGF-β1 in transformed cells. Copyright © 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Cell Line -
- Cell Movement - drug effects
- Cell Proliferation - drug effects
- Cell Transformation, Neoplastic -
- Epithelial-Mesenchymal Transition - drug effects
- Gene Expression Regulation - drug effects
- Humans -
- Keratinocytes - cytology
- Keratinocytes - drug effects
- Keratinocytes - metabolism
- Keratinocytes - pathology
- Mice -
- Neoplasm Invasiveness -
- Nuclear Proteins - deficiency
- Nuclear Proteins - genetics
- Nuclear Proteins - metabolism
- Plasminogen Activator Inhibitor 1 - genetics
- Transforming Growth Factor beta1 - pharmacology
- Urokinase-Type Plasminogen Activator - genetics
- Find related publications in this database (Keywords)
- Transforming growth factor-beta 1
- Sky-interacting protein
- Epithelial-mesenchymal transition
- Urokinase type plasminogen activator
- Plasminogen activator inhibitor type-1
- Migration