Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Okic-Djordjevic, I; Trivanovic, D; Krstic, J; Jaukovic, A; Mojsilovic, S; Santibanez, JF; Terzic, M; Vesovic, D; Bugarski, D.
GE132+Natural: Novel promising dietetic supplement with antiproliferative influence on prostate, colon, and breast cancer cells.
J BUON. 2013; 18(2): 504-510.
Web of Science
PubMed
- Co-authors Med Uni Graz
- Krstic Jelena
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- Abstract:
- Natural products have been investigated for promising new leads in pharmaceutical development. The purpose of this study was to analyze the biological effect of GE132+Natural, a novel supplement consisting of 5 compounds: Resveratrol, Ganoderma lucidum, Sulforaphane, Lycopene and Royal jelly. The antiproliferative activity of GE132+Natural was tested on 3 different human cancer cell lines: MCF7 (breast cancer cells), PC3 (prostate cancer cells), and SW480 (colon cancer cells), as well as on EA.hy 926 (normal human endothelial cell line). In addition, the cytotoxicity of GE132+- Natural on the proliferation of primary human mesenchymal stem cells isolated from dental pulp (DP=MSC), along with its in vitro impact on different peripheral blood parameters, was determined. The results revealed high antiproliferative activity of GE132+Natural on all tested cancer cell lines (PC3, MCF7 and SW480), as well as on the EA.hy 926 endothelial cell line in a dose-dependent manner. However, applied in a wide range of concentrations GE132+Natural did not affect both the proliferation of primary mesenchymal stem cells and the peripheral blood cells counts. The data obtained demonstrated that GE132+Natural is effective in inhibiting cancer cell proliferation, indicating its potential beneficial health effects. In addition, the results pointed that adult mesenchymal stem cells might be valuable as a test system for evaluating the toxicity and efficacy of new medicines or chemicals.
- Find related publications in this database (using NLM MeSH Indexing)
- Antineoplastic Agents - pharmacology
- Antineoplastic Agents - toxicity
- Blood Cells - drug effects
- Breast Neoplasms - pathology
- Cell Proliferation - drug effects
- Colonic Neoplasms - pathology
- Dietary Supplements - toxicity
- Dose-Response Relationship, Drug -
- Drug Combinations -
- Endothelial Cells - drug effects
- Female -
- Humans -
- MCF-7 Cells -
- Male -
- Mesenchymal Stem Cells - drug effects
- Prostatic Neoplasms - pathology
- Find related publications in this database (Keywords)
- antiproliferative effect
- breast cancer
- colon cancer
- dietary supplement GE132+Natural
- prostate cancer