Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Zhang, F; Li, M; Wang, J; Liang, X; Su, Y; Wang, W.
Finding New Tricks for Old Drugs: Tumoricidal Activity of Non-Traditional Antitumor Drugs.
AAPS PharmSciTech. 2016; 17(3):539-552
Doi: 10.1208/s12249-016-0518-y
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Zhang Fangrong
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- Abstract:
- Chemotherapy, a traditional method, plays an important role in tumor therapy. Currently, common clinical antitumor drugs have several defects like poor efficacy, side effects, etc. Furthermore, developing new antitumor drugs takes a long time and requires many resources. Recent studies have found that oldies are newbies for the oncologist, such as flavonoid, metformin, aspirin, etc. These non-traditional antitumor drugs (NTADs) are widely used in management of non-cancer diseases, which gained FDA approval for treatment of patients. Increasingly, studies about antitumor action of NTADs have attracted many researchers' interests. A giant amount of studies showed a decrease in cancer incidence in NTAD-treated patients. Several reports outlined a direct inhibitory effect of NTADs on cancer cell growth and antitumoral actions. This review summarized the research progress on antitumor effects of ten NTADs. Retrospective and meta-analyses of trials also showed that these NTADs had preventive effects against cancer in vitro and in vivo. These drugs represent a promising option for cancer treatment, which have clear benefits including clinical safety, obvious curative effect, and saving medical and health resources. Judged from previous reports, future studies will yield valuable data about the profitable effects of these drugs. With a better understanding of its mechanisms of antitumor activity, NTADs may become available for combination with chemotherapy or targeted therapy in clinic.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Antineoplastic Agents - chemistry
- Antineoplastic Agents - therapeutic use
- Aspirin - chemistry
- Aspirin - therapeutic use
- Clinical Trials as Topic - methods
- Flavonoids - chemistry
- Flavonoids - therapeutic use
- Humans -
- Metformin - chemistry
- Metformin - therapeutic use
- Neoplasms - drug therapy
- Neoplasms - metabolism
- Retrospective Studies -
- Find related publications in this database (Keywords)
- chemotherapy
- non-traditional anticarcinogen
- pharmacological action
- tumoricidal activity