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Wolf, P; Müllegger, R; Cerroni, L; Aigner, R; Fueger, G; Höfler, G; Derbaschnig, J; Kerl, H.
Photoaccentuated erythroderma associated with CD4+ T lymphocytopenia: successful treatment with 5-methoxypsoralen and UVA, interferon alfa-2b, and extracorporeal photopheresis.
J Am Acad Dermatol. 1996; 35(2 Pt 2):291-294 Doi: 10.1016%2FS0190-9622%2896%2990651-9 (- Case Report)
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Leading authors Med Uni Graz: Wolf Peter
Co-authors Med Uni Graz: Aigner Reingard; Cerroni Lorenzo; Höfler Gerald; Kerl Helmut; Muellegger Robert
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Abstract:: We describe a 53-year-old HIV-negative white man who had chronic CD4+ T lymphocytopenia and photoaccentuated erythroderma with lymphoma-like histologic changes. The erythroderma completely responded to 5-methoxypsoralen and UVA (PUVA), interferon alfa-2b, and extracorporeal photopheresis. During therapy opportunistic skin infections, including tinea corporis, warts, and disseminated molluscum contagiosum, developed. Although the patient met the current definition of idiopathic CD4+ T lymphocytopenia (ICTL), we cannot rule out the possibility that this peripheral CD4+ T lymphocytopenia resulted from sequestration of CD4+ T lymphocytes in erythrodermic skin.
Find related publications in this database (using NLM MeSH Indexing): Dermatitis, Exfoliative - drug therapy; HIV Seronegativity - drug therapy; Humans - drug therapy; Interferon Alfa-2b - therapeutic use; Lymphoma, T-Cell, Cutaneous - pathology; Male - pathology; Methoxsalen - analogs and derivatives; Middle Aged - analogs and derivatives; Molluscum Contagiosum - etiology; Opportunistic Infections - etiology; PUVA Therapy - etiology; Photopheresis - etiology; Photosensitivity Disorders - drug therapy; Skin Neoplasms - pathology; T-Lymphocytopenia, Idiopathic CD4-Positive - drug therapy; Tinea - etiology; Warts - etiology