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Strauss, RW; Kong, X; Bittencourt, MG; Ho, A; Jha, A; Schönbach, EM; Ahmed, MI; Muñoz, B; Ervin, AM; Michaelides, M; Birch, DG; Sahel, JA; Sunness, JS; Zrenner, E; Bagheri, S; Ip, M; Sadda, S; West, S; Scholl, HPN; for the SMART Study Group.
Scotopic Microperimetric Assessment of Rod Function in Stargardt Disease (SMART) Study: Design and Baseline Characteristics (Report No. 1).
Ophthalmic Res. 2019; 61(1): 36-43. Doi: 10.1159/000488711 [OPEN ACCESS]
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Leading authors Med Uni Graz: Strauß Rupert
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Abstract:: To describe the study design and characteristics at first visit of participants in the longitudinal Scotopic Microperimetric Assessment of Rod Function in Stargardt Disease (SMART) study. Scotopic microperimetry (sMP) was performed in one designated study eye in a subset of participants with molecularly proven ABCA4-associated Stargardt disease (STGD1) enrolled in a multicenter natural history study (ProgStar). Study visits were every 6 months over a period ranging from 6 to 24 months, and also included fundus autofluorescence (FAF). SMART enrolled 118 participants (118 eyes). At the first visit of SMART, the mean sensitivity in mesopic microperimetry was 11.48 (±5.05; range 0.00-19.88) dB and in sMP 11.25 (±5.26; 0-19.25) dB. For FAF, all eyes had a lesion of decreased autofluorescence (mean lesion size 3.62 [±3.48; 0.10-21.46] mm2), and a total of 76 eyes (65.5%) had a lesion of definitely decreased autofluorescence with a mean lesion size of 3.46 (±3.60; 0.21-21.46) mm2. Rod function is impaired in STGD1 and can be assessed by sMP. Testing rod function may serve as a potential outcome measure for future clinical treatment trials. This is evaluated in the SMART study. © 2018 S. Karger AG, Basel.
Find related publications in this database (Keywords): Scotopic microperimetry; Mesopic microperimetry; Stargardt disease; Endpoints; Clinical trials