Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Berti, A; Dejaco, C.
Update on the epidemiology, risk factors, and outcomes of systemic vasculitides.
BEST PRACT RES CL RH. 2018; 32(2): 271-294.
Doi: 10.1016/j.berh.2018.09.001
Web of Science
PubMed
FullText
FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Dejaco Christian
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- Abstract:
- Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) and giant cell arteritis (GCA) are the most common primary systemic vasculitides of the adult population, while polymyalgia rheumatica (PMR) is a clinical syndrome often associated with GCA. Incidence and prevalence rates of AAV have been increasing in the last decades, whereas those of GCA and PMR have remained stable. The mutual interplay between environmental and genetic risk factors leading to the development of these diseases has been further analyzed in the last years. The role of infectious agents has repeatedly been studied with regard to Staphylococcus aureus, associated with relapse in granulomatosis with polyangiitis, and Herpes zoster, potentially contributing to GCA development. Remission of disease and prevention of disease-related complications are the most important outcomes for all systemic vasculitides. Although these goals are achieved in the majority of patients receiving modern therapies, the prevention of treatment-related complications, especially glucocorticoid side effects, is still an unmet need that is common to AAV, GCA, and PMR. Copyright © 2018 Elsevier Ltd. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Humans -
- Incidence -
- Outcome Assessment (Health Care) -
- Prevalence -
- Risk Factors -
- Systemic Vasculitis - epidemiology
- Systemic Vasculitis - etiology
- Find related publications in this database (Keywords)
- Vasculitis
- Mortality
- Relapse
- ANCA-Associated vasculitis
- Granulomatosis with polyangiitis
- Eosinophilic granulomatosis with polyangiitis
- Microscopic polyangiitis
- Polymyalgia rheumatics
- Giant cell arteritis
- Takayasu arteritis