Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Sorbye, H; Baudin, E; Borbath, I; Caplin, M; Chen, J; Cwikla, JB; Frilling, A; Grossman, A; Kaltsas, G; Scarpa, A; Welin, S; Garcia-Carbonero, R; ENETS 2016 Munich Advisory Board Participants.
Unmet Needs in High-Grade Gastroenteropancreatic Neuroendocrine Neoplasms (WHO G3).
NEUROENDOCRINOLOGY. 2019; 108(1): 54-62.
Doi: 10.1159/000493318
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- Study Group Mitglieder der Med Uni Graz:
- Krejs Günter Josef
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- Abstract:
- Gastroenteropancreatic (GEP) neuroendocrine neoplasms (NEN) are classified based on morphology and graded based on their proliferation rate as either well-differentiated low-grade (G1 to G2) neuroendocrine tumors (NET) or poorly differentiated high-grade (G3) neuroendocrine carcinomas (NEC). Recently, a new subgroup of well-differentiated high-grade pancreatic tumors (NET G3) has been defined. The GEP NEN G3 group consisting of both NEC and NET G3 has recently been shown to be a quite heterogeneous patient group concerning prognosis and treatment benefit, depending on factors such as the primary tumor site, differentiation, proliferation rate, and molecular alterations. In this review we discuss the existing data on diagnostics, treatment, and biomarkers in this patient group, the unmet needs, and the future perspectives. © 2018 S. Karger AG, Basel.
- Find related publications in this database (Keywords)
- Neuroendocrine neoplasm
- Neuroendocrine tumor
- Neuroendocrine carcinoma