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Gewählte Publikation:

Cerwenka, H; Khoschsorur, G; Bacher, H; Werkgartner, G; El-Shabrawi, A; Quehenberger, F; Rabl, H; Mischinger, HJ.
Normothermic liver ischemia and antioxidant treatment during hepatic resections.
Free Radic Res. 1999; 30(6):463-469 Doi: 10.1080/10715769900300501
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Führende Autor*innen der Med Uni Graz
Cerwenka Herwig
Co-Autor*innen der Med Uni Graz
Bacher Heinz
Khoschsorur Gholamali
Mischinger Hans-Jörg
Quehenberger Franz
Werkgartner Georg
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Abstract:
The purpose of our study was to evaluate the clinical impact of reperfusion injury after normothermic ischemia during major liver resections and the effect of an intraoperative antioxidant infusion. This prospective randomized study comprised 50 patients; half of them (treatment group) were given an antioxidant infusion containing tocopherol and ascorbate immediately prior to reperfusion onset. Venous blood samples for the determination of MDA-TBARS (malondialdehyde-thiobarbituric acid reactive substances) by a HPLC-based test as a marker of lipid peroxidation were taken prior to ischemia, 30 min after reperfusion onset and at the end of the operation. In the control group there was a significant increase of MDA-TBARS (p = 0.001) at 30 min after reperfusion onset. At the end of the operation the values had returned to the initial level. The treatment group showed only a marginal increase (p-value for the difference between the two groups: 0.007). After exclusion of the patients with histologically proven advanced cirrhosis the increase in the control group (p < 0.001) and the difference between the increase in the two groups (p = 0.001) became more significant. Prothrombin time was also significantly better in the treatment group (p = 0.003). Postoperative complications such as prolonged liver failure, bleeding disorders and infections were seen more often in the control group. In our study MDA-TBARS was increased after liver ischemia, but in patients with advanced cirrhosis the effect was smaller or even absent. This increase and possible clinical consequences of reperfusion injury could be reduced by intraoperative administration of an antioxidant infusion.
Find related publications in this database (using NLM MeSH Indexing)
Antioxidants - adverse effects
Ascorbic Acid - adverse effects
Humans -
Lipid Peroxidation - drug effects
Liver - blood supply
Liver Cirrhosis - metabolism
Malondialdehyde - blood
Postoperative Complications -
Prothrombin Time -
Reperfusion Injury - blood
Temperature -
Thiobarbituric Acid Reactive Substances - analysis
Time Factors -
Transaminases - metabolism
Vitamin E - adverse effects

Find related publications in this database (Keywords)
Ischemia-Reperfusion Injury
Normothermic Liver Ischemia
Lipid Peroxidation
Antioxidant Treatment
Liver Surgery
Malondialdehyde
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