Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Zittermann, A; Ernst, JB; Prokop, S; Fuchs, U; Gruszka, A; Dreier, J; Kuhn, J; Knabbe, C; Berthold, HK; Gouni-Berthold, I; Pilz, S; Gummert, JF; Paluszkiewicz, L.
Vitamin D supplementation of 4000 IU daily and cardiac function in patients with advanced heart failure: The EVITA trial.
Int J Cardiol. 2019; 280:117-123
Doi: 10.1016/j.ijcard.2019.01.027
Web of Science
PubMed
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FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Pilz Stefan
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- Abstract:
- Data regarding the effects of vitamin D on cardiac function are inconclusive. In a post-hoc analysis of the EVITA (Effect of vitamin D on mortality in heart failure) trial, we investigated whether a daily vitamin D3 supplement of 4000 IU for three years affects echocardiography parameters like left ventricular end-diastolic diameter (LVEDD), LV end-systolic diameter (LVESD), and LV ejection fraction (LVEF) in patients with advanced heart failure (HF) and 25‑hydroxyvitamin D levels <75 nmol/L. Of 400 patients enrolled, 199 were assigned to vitamin D and 201 to placebo. We assessed time × treatment interaction effects using linear mixed models and analyzed in subgroups vitamin D effects at 12 and 36 months post-randomization using analysis of covariance with adjustments for baseline values. At baseline, values of LVEDD, LVESD, and LVEF were 67.5 ± 10.5 mm, 58.9 ± 12.0 mm, and 30.47 ± 10.2%, respectively. There were no time × treatment interaction effects on LV echocardiographic parameters in the entire study cohort, neither at 12 months nor at 36 months post-randomization (P-values > 0.05). However, in the subgroup of patients aged ≥50 years, vitamin D treatment was associated with an increase in LVEF of 2.73% (95%CI: 0.14 to 5.31%) at 12 months post-randomization (n = 311). The increase was slightly attenuated to 2.60% (95%CI: -2.47 to 7.67%) at 36 months post-randomization (n = 242). Our data indicate that vitamin D supplementation does not significantly improve cardiac function in all patients with advanced HF. However, vitamin D probably improves LV function in HF patients aged ≥50 years. Copyright © 2019 Elsevier B.V. All rights reserved.
- Find related publications in this database (Keywords)
- Vitamin D
- Heart failure
- Left ventricular ejection fraction
- Randomized controlled trial
- Echocardiography