Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
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Tomić Paradžik, M; Drenjančević, D; Presečki-Stanko, A; Kopić, J; Talapko, J; Zarfel, G; Bedenić, B.
Hidden Carbapenem Resistance in OXA-48 and Extended-Spectrum β-Lactamase-Positive Escherichia coli.
Microb Drug Resist. 2019; 25(5):696-702
Doi: 10.1089/mdr.2018.0309
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- Zarfel Gernot
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- Abstract:
- The purpose of this study was to report the identification OXA-48 carbapenemase in seven extended-spectrum β-lactamase (ESBL)-positive Escherichia coli clinical isolates, fully susceptible to all carbapenems by disk diffusion and E-test methods, but with borderline minimal inhibitory concentration (MIC) values of ertapenem. This report points to the necessity for determination of carbapenem MICs in ESBL-positive E. coli isolates and additional phenotypic testing for carbapenemases in all isolates with borderline ertapenem MIC defined by EUCAST. The isolates showed a high level of resistance to expanded-spectrum cephalosporins because of the production of an additional ESBL belonging to CTX-M family. All isolates and their respective tranconjugants were found to possess L plasmid. Pulsed-field gel electrophoresis analysis revealed two clusters containing highly related isolates. The global spread of multidrug-resistant E. coli should be monitored closely because of the ability of isolates to rapidly obtain additional antibiotic resistance traits such as plasmid-mediated OXA-48 genes.
- Find related publications in this database (Keywords)
- Escherichia coli
- beta-lactamases
- ESBL
- carbapenemases
- OXA-48