Sourij, C; Obermayer, A; Sourij, H.
SGLT-inhibitors as a therapeutic option for patients with type 1 diabetes
AUST J CLIN ENDOCR M. 2018; 11(4): 122-126.
Doi: 10.1007/s41969-018-0050-7
[OPEN ACCESS] Web of ScienceFullTextFullText_MUG
While insulin therapy is vital for subjects with type 1 diabetes, supporting glucose lowering agents are needed, helping to optimize glycaemic control while not increasing hypoglycaemia risk. Sodium glucose co-transporter (SGLT)-inhibitors are lowering blood glucose by increasing glucosuria, a mechanism also working in type 1 diabetes. This review summarizes current efficacy data of SGLT-inhibitors in type 1 diabetes and discusses the increased risk for euglycaemic ketoacidosis associated with this drug class.
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